| Literature DB >> 8684459 |
X J Yang1, V V Ogryzko, J Nishikawa, B H Howard, Y Nakatani.
Abstract
The adenoviral oncoprotein E1A induces progression through the cell cycle by binding to the products of the p300/CBP and retinoblastoma gene families. A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A. Exogenous expression of P/CAF in HeLa cells inhibits cell-cycle progression and counteracts the mitogenic activity of E1A. E1A disturbs the normal cellular interaction between p300/CBP and its associated histone acetylase.Entities:
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Year: 1996 PMID： 8684459 DOI： 10.1038/382319a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962