PURPOSE: We characterized small intestinal submucosa regenerated canine bladder. MATERIALS AND METHODS: We subjected 15-month small intestinal submucosa regenerated canine bladder strips to in vitro muscle bath compliance, contractility testing and immunohistochemical staining. RESULTS: Compliance studies demonstrated no significant difference between small intestinal submucosa regenerated and control bladders, which were 30-fold more compliant than native small intestinal submucosal graft material. Contractility studies demonstrated contractile responses and innervation similar to those of normal canine bladder. Afferent nerves were demonstrated through immunohistochemical techniques. CONCLUSIONS: These characteristics further support the regenerative capacity of small intestinal submucosa and its potential use as a bladder augmentation material.
PURPOSE: We characterized small intestinal submucosa regenerated canine bladder. MATERIALS AND METHODS: We subjected 15-month small intestinal submucosa regenerated canine bladder strips to in vitro muscle bath compliance, contractility testing and immunohistochemical staining. RESULTS: Compliance studies demonstrated no significant difference between small intestinal submucosa regenerated and control bladders, which were 30-fold more compliant than native small intestinal submucosal graft material. Contractility studies demonstrated contractile responses and innervation similar to those of normal canine bladder. Afferent nerves were demonstrated through immunohistochemical techniques. CONCLUSIONS: These characteristics further support the regenerative capacity of small intestinal submucosa and its potential use as a bladder augmentation material.
Authors: Fadee G Mondalek; Benjamin J Lawrence; Bradley P Kropp; Brian P Grady; Kar-Ming Fung; Sundar V Madihally; Hsueh-Kung Lin Journal: Biomaterials Date: 2008-03 Impact factor: 12.479
Authors: Matthew Brovold; Joana I Almeida; Iris Pla-Palacín; Pilar Sainz-Arnal; Natalia Sánchez-Romero; Jesus J Rivas; Helen Almeida; Pablo Royo Dachary; Trinidad Serrano-Aulló; Shay Soker; Pedro M Baptista Journal: Adv Exp Med Biol Date: 2018 Impact factor: 2.622