The immune adherence phenomenon in experimental candidiasis.

The immune adherence reaction was shown in experimental candidiasis. This phenomenon has not been previously described for candidiasis, to the best of our knowledge. Forty-eight sera of guinea pigs inoculated with a single or several inoculations of live Candida albicans were tested at different time intervals after inoculation for anti C. albicans antibodies detectable by the immune adherence reaction. From the 14th day after inoculation, a positive immune adherence reaction was observed with titer and strength increasing as time passed after inoculation and as the number of inoculations increased. All the sera were tested parallely in agglutination and indirect mast cell degranulation tests. The significance of the data obtained is discussed.