PURPOSE: We explored the immunohistochemical expression of prostate specific antigen (PSA) in pancreas and salivary glands. MATERIALS AND METHODS: We investigated 62 specimens from male and female subjects, representing normal cases and several pathological conditions of pancreas and salivary glands. Two commercially available monoclonal antisera for PSA and 1 for prostatic acid phosphatase were used. RESULTS: A consistently positive reaction for PSA and prostatic acid phosphatase, independent of patient sex, was noted in ductal cells of normal pancreas and normal salivary glands, as well as pleomorphic adenoma, adenocarcinoma and all oncocytic epithelial cells of Warthin's tumor. Reaction was absent in normal stromal and acinar cells, and squamous carcinoma. CONCLUSIONS: PSA is detectable in normal and cancer tissues far from the prostate. Therefore, we may not entirely rely on specificity of PSA alone to diagnose metastatic prostate cancer.
PURPOSE: We explored the immunohistochemical expression of prostate specific antigen (PSA) in pancreas and salivary glands. MATERIALS AND METHODS: We investigated 62 specimens from male and female subjects, representing normal cases and several pathological conditions of pancreas and salivary glands. Two commercially available monoclonal antisera for PSA and 1 for prostatic acid phosphatase were used. RESULTS: A consistently positive reaction for PSA and prostatic acid phosphatase, independent of patient sex, was noted in ductal cells of normal pancreas and normal salivary glands, as well as pleomorphic adenoma, adenocarcinoma and all oncocytic epithelial cells of Warthin's tumor. Reaction was absent in normal stromal and acinar cells, and squamous carcinoma. CONCLUSIONS:PSA is detectable in normal and cancer tissues far from the prostate. Therefore, we may not entirely rely on specificity of PSA alone to diagnose metastatic prostate cancer.
Authors: Dmitry Koulikov; Maura C Mohler; Diana C Mehedint; Kristopher Attwood; Gregory E Wilding; James L Mohler Journal: J Urol Date: 2014-05-21 Impact factor: 7.450
Authors: Emma E van der Toom; Haley D Axelrod; Jean J de la Rosette; Theo M de Reijke; Kenneth J Pienta; Kenneth C Valkenburg Journal: Nat Rev Urol Date: 2019-01 Impact factor: 14.432
Authors: Angela Queisser; Susanne A Hagedorn; Martin Braun; Wenzel Vogel; Stefan Duensing; Sven Perner Journal: Mod Pathol Date: 2014-06-13 Impact factor: 7.842
Authors: Tamara Sequeiros; Marta García; Melania Montes; Mireia Oliván; Marina Rigau; Eva Colás; Inés de Torres; Juan Morote; Jaume Reventós; Andreas Doll Journal: Biomed Res Int Date: 2013-11-25 Impact factor: 3.411