| Literature DB >> 8681902 |
K Murakami1, T Sugimoto, M Woo, N Nishida, H Muro.
Abstract
We analyzed urinary valproate (VPA) metabolites and carnitine concentrations in a child who accidentally ingested 400 mg/kg VPA. The concentration of 4-en VPA, the presumed major factor in VPA-induced hepatotoxicity, was markedly increased, without liver dysfunction or hyperammonemia. The other major abnormality was decreased beta-oxidation and markedly increased omega-oxidation. After L-carnitine supplementation, VPA metabolism returned to normal. The level of valproylcarnitine was not increased and therefore was not affected by L-carnitine. L-Carnitine may be useful in treating patients with coma after VPA overdose.Entities:
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Year: 1996 PMID： 8681902 DOI： 10.1111/j.1528-1157.1996.tb00634.x
Source DB: PubMed Journal: Epilepsia ISSN： 0013-9580 Impact factor: 5.864