| Literature DB >> 8681040 |
M Kasper1, A Bierhaus, A Whyte, R M Binns, D Schuh, M Müller.
Abstract
The distribution of CD44s and CD44v molecules in normal and injured lung tissue of rats and mini-pigs was studied by examining the immunohistochemical binding of monoclonal antibodies against CD44 isoforms. We showed that the expression of CD44v and CD44s varies greatly among different pulmonary fibrosis samples and that some tissues express either enhanced expression of CD44s, particularly in the interstitium and on alveolar macrophages, or very low levels of CD44v in the alveolar epithelium. Normal type II pneumocytes expressed the CD44s and CD44v molecules at the basolateral aspect of the cell. Such localisation favours a role for CD44 in epithelial cell-fibroblast interaction during lung development and repair.Entities:
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Year: 1996 PMID： 8681040 DOI： 10.1007/bf01462295
Source DB: PubMed Journal: Histochem Cell Biol ISSN： 0948-6143 Impact factor: 4.304