OBJECTIVES: To determine the accuracy and precision of the Accutrend GC (AGC) in measuring cholesterol totals (CT) and its use as a screening test to detect hypercholesterolaemia. DESIGN AND PARTICIPANTS: Venous blood was drawn from 104 patients to measure CT by an enzymatic method (Hitachi 717). At the same time, their capillary blood was also measured with the AGC on two consecutive occasions. Values were divided in three groupings: CT > 149 mg/dl and < or = 199 mg/dl (n = 27); CT > 199 mg/dl and < or = 249 mg/dl (n = 59); and CT > or = 250 mg/dl (n = 18). Accuracy was calculated by obtaining the mean differences (MD) and the confidence intervals of the values obtained with the AGC in the three groupings and comparing them with the values obtained by the laboratory method. Precision was assessed by correlation, the comparison of paired means and the mean coefficient of variation of the values obtained with the AGC in the two successive measurements. MAIN MEASUREMENTS AND FINDINGS: In each grouping the MD of the values obtained with the AGC were lower than those obtained by the laboratory method, respectively. CONCLUSIONS: The AGC is useful as a screening test to detect hypercholesterolaemia, because of its high accuracy and precision. As it also determines glucose it is very useful for diabetics.
OBJECTIVES: To determine the accuracy and precision of the Accutrend GC (AGC) in measuring cholesterol totals (CT) and its use as a screening test to detect hypercholesterolaemia. DESIGN AND PARTICIPANTS: Venous blood was drawn from 104 patients to measure CT by an enzymatic method (Hitachi 717). At the same time, their capillary blood was also measured with the AGC on two consecutive occasions. Values were divided in three groupings: CT > 149 mg/dl and < or = 199 mg/dl (n = 27); CT > 199 mg/dl and < or = 249 mg/dl (n = 59); and CT > or = 250 mg/dl (n = 18). Accuracy was calculated by obtaining the mean differences (MD) and the confidence intervals of the values obtained with the AGC in the three groupings and comparing them with the values obtained by the laboratory method. Precision was assessed by correlation, the comparison of paired means and the mean coefficient of variation of the values obtained with the AGC in the two successive measurements. MAIN MEASUREMENTS AND FINDINGS: In each grouping the MD of the values obtained with the AGC were lower than those obtained by the laboratory method, respectively. CONCLUSIONS: The AGC is useful as a screening test to detect hypercholesterolaemia, because of its high accuracy and precision. As it also determines glucose it is very useful for diabetics.
Authors: Aldo Scafoglieri; Jonathan Tresignie; Steven Provyn; Jan Pieter Clarys; Ivan Bautmans Journal: Biochem Med (Zagreb) Date: 2012 Impact factor: 2.313