OBJECTIVE: To find out if propranolol, a non-cardioselective beta-blocker, can reduce the anxiety associated with day case surgery. DESIGN: Prospective randomized double blind trial. SETTING: University hospital, Ireland. SUBJECTS: An unselected group of 53 patients undergoing day case surgery. INTERVENTION: Subjects randomised to receive either propranolol (10 mg) or placebo on the morning of operation. MAIN OUTCOME MEASURES: Blood pressure; pulse, anxiety, pain score and patient satisfaction. RESULTS:Mean (SD) Hospital Anxiety and Depression score was significantly lower in the propranolol group than in the control group (2.5 (0.7) compared with 4.6 (0.7), p < 0.0001) before discharge. CONCLUSION: A low dose of propranolol given on the morning of day case surgery significantly reduced patients' anxiety.
RCT Entities:
OBJECTIVE: To find out if propranolol, a non-cardioselective beta-blocker, can reduce the anxiety associated with day case surgery. DESIGN: Prospective randomized double blind trial. SETTING: University hospital, Ireland. SUBJECTS: An unselected group of 53 patients undergoing day case surgery. INTERVENTION: Subjects randomised to receive either propranolol (10 mg) or placebo on the morning of operation. MAIN OUTCOME MEASURES: Blood pressure; pulse, anxiety, pain score and patient satisfaction. RESULTS: Mean (SD) Hospital Anxiety and Depression score was significantly lower in the propranolol group than in the control group (2.5 (0.7) compared with 4.6 (0.7), p < 0.0001) before discharge. CONCLUSION: A low dose of propranolol given on the morning of day case surgery significantly reduced patients' anxiety.
Authors: Jennifer K MacCormack; Emma L Armstrong-Carter; Monica M Gaudier-Diaz; Samantha Meltzer-Brody; Erica K Sloan; Kristen A Lindquist; Keely A Muscatell Journal: Psychosom Med Date: 2021 Nov-Dec 01 Impact factor: 4.312
Authors: Yanfeng Wang; Zhijun Wang; Zhong Zuo; Brian Tomlinson; Benjamin T K Lee; Michael B Bolger; Moses S S Chow Journal: AAPS J Date: 2013-04-19 Impact factor: 4.009
Authors: Serge A Steenen; Arjen J van Wijk; Geert J M G van der Heijden; Roos van Westrhenen; Jan de Lange; Ad de Jongh Journal: J Psychopharmacol Date: 2015-10-20 Impact factor: 4.153
Authors: G R Constantine; P Ranasinghe; P Weeratunga; C Weeraratne; P Galappatthy; S Rajapakse; U Senarath; P Katulanda Journal: Trials Date: 2017-03-14 Impact factor: 2.279