Literature DB >> 8679151

A new biochemical assay in the diagnostic management of nasal cerebrospinal fluid leakage.

M J Middelweerd1, N de Vries, J Calliauw, G J van Kamp.   

Abstract

A new method for the detection of cerebrospinal fluid (CSF) leakage is described, and is a refinement of the method originally reported by Oberascher and Arrer in 1986. Immuno-electrophoretic measurements are performed in a two-buffer system, making the test easier to do and providing qualitatively better images. Genetic variants of transferrin (which has a general population incidence of 2-4%) can be discriminated from false-positive test results in affected families. The test described is recommended as the method of choice for initial screening of suspected CSF leakage.

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Year:  1995        PMID： 8679151     DOI： 10.1007/bf00178272

Source DB:  PubMed          Journal:  Eur Arch Otorhinolaryngol        ISSN： 0937-4477            Impact factor:   2.503


  8 in total

1.  Method for the identification and localization of cerebrospinal fluid, rhinorrhea and otorrhea.

Authors:  F R KIRCHNER; G O PROUD
Journal:  Laryngoscope       Date:  1960-07       Impact factor: 3.325

2.  Starch gel electrophoresis in a discontinous system of buffers.

Authors:  M D POULIK
Journal:  Nature       Date:  1957-12-28       Impact factor: 49.962

3.  A modern concept of cerebrospinal fluid diagnosis in oto- and rhinorrhea.

Authors:  G Oberascher
Journal:  Rhinology       Date:  1988-06       Impact factor: 3.681

4.  The diagnosis of CSF fistulae on the basis of detection of beta 2-transferrin by polyacrylamide gel electrophoresis and immunoblotting.

Authors:  P W Reisinger; K Hochstrasser
Journal:  J Clin Chem Clin Biochem       Date:  1989-03

5.  Efficiency of various methods of identifying cerebrospinal fluid in oto- and rhinorrhea.

Authors:  G Oberascher; E Arrer
Journal:  ORL J Otorhinolaryngol Relat Spec       Date:  1986       Impact factor: 1.538

6.  Immunofixation to quantify beta 2-transferrin in cerebrospinal fluid to detect leakage of cerebrospinal fluid from skull injury.

Authors:  D L Zaret; N Morrison; R Gulbranson; D F Keren
Journal:  Clin Chem       Date:  1992-09       Impact factor: 8.327

7.  A new method for using fluorescein to demonstrate oto- and rhinoliquorrhea. I. Sample preparation by electrophoresis and photometric identification of fluorescein.

Authors:  G Oberascher; E Arrer
Journal:  Arch Otorhinolaryngol       Date:  1986

8.  Studies on the transferrins of adult serum, cord serum, and cerebrospinal fluid. The effect of neuraminidase.

Authors:  W C PARKER; A G BEARN
Journal:  J Exp Med       Date:  1962-01-01       Impact factor: 14.307
  8 in total
  2 in total

1.  Endonasal endoscopic closure of cerebrospinal fluid rhinorrhea.

Authors:  S Schmerber; C Righini; J P Lavielle; J G Passagia; E Reyt
Journal:  Skull Base       Date:  2001-02

2.  Endoscopic endonasal approach of congenital meningoencephalocele surgery: first reported case in lithuania.

Authors:  Svajūnas Balseris; Giedrius Strazdas; Saulius Ročka; Tomas Jakštas
Journal:  Case Rep Otolaryngol       Date:  2015-03-19
  2 in total

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