| Literature DB >> 8679128 |
Abstract
Metal-induced autoimmunity is a well established but poorly understood phenomenon. Recent work has begun to elucidate the molecular interactions of metal ions with immune cells and self-proteins. Metal-induced presentation of cryptic self-peptides emerges as a possible mechanism for activation of 'metal-specific' T cells, challenging the hypothesis of a random polyclonal activation of T and B cells by metals. A preferential T-helper cell type 2 response is involved in metal ion induced systemic autoimmune disease.Entities:
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Year: 1995 PMID: 8679128 DOI: 10.1016/0952-7915(95)80056-5
Source DB: PubMed Journal: Curr Opin Immunol ISSN: 0952-7915 Impact factor: 7.486