Literature DB >> 8679127

Glutamic acid decarboxylase and other autoantigens in IDDM.

G T Nepom1.   

Abstract

Autoantigens in insulin-dependent diabetes serve as diagnostic markers and as potential therapeutic immunomodulators. Recent studies have focused particularly on two well studied molecules, glutamic acid decarboxylase and insulin, as well as several new antigens that have been recently identified, recognized by antibody and/or cell-mediated immune responses in diabetic patients. Temporal aspects of antigen exposure, antigen processing of specific peptide antigens, and the interplay between specific antigens, MHC genetics, and host T-cell responses remain to be explored.

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Year:  1995        PMID： 8679127     DOI： 10.1016/0952-7915(95)80055-7

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  8 in total

1.  Detection of glutamic acid decarboxylase-activated T cells with I-Ag7 tetramers.

Authors:  C P Liu; K Jiang; C H Wu; W H Lee; W J Lin
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-19       Impact factor: 11.205

2.  T cell response pattern to glutamic acid decarboxylase 65 (GAD65) peptides of newly diagnosed type 1 diabetic patients sharing susceptible HLA haplotypes.

Authors:  F Rharbaoui; A Mayer; C Granier; M Bouanani; C Thivolet; B Pau; J Orgiazzi; A M Madec
Journal:  Clin Exp Immunol       Date:  1999-07       Impact factor: 4.330

3.  Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65).

Authors:  G T Nepom; J D Lippolis; F M White; S Masewicz; J A Marto; A Herman; C J Luckey; B Falk; J Shabanowitz; D F Hunt; V H Engelhard; B S Nepom
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-13       Impact factor: 11.205

Review 4.  Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes.

Authors:  Jane H Buckner; Gerald T Nepom
Journal:  J Autoimmun       Date:  2016-03-03       Impact factor: 7.094

5.  Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice.

Authors:  Felix J Baker; Mark Lee; Yueh-hsiu Chien; Mark M Davis
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-24       Impact factor: 11.205

6.  Formation of pancreatic β-cells from precursor cells contributes to the reversal of established type 1 diabetes.

Authors:  Tobechukwu K Ukah; Alexis N Cattin-Roy; George E Davis; Habib Zaghouani
Journal:  Cell Immunol       Date:  2021-04-09       Impact factor: 4.178

7.  Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes.

Authors:  P Höglund; J Mintern; C Waltzinger; W Heath; C Benoist; D Mathis
Journal:  J Exp Med       Date:  1999-01-18       Impact factor: 14.307

Review 8.  What the HLA-I!-Classical and Non-classical HLA Class I and Their Potential Roles in Type 1 Diabetes.

Authors:  Rebecca C Wyatt; Giacomo Lanzoni; Mark A Russell; Ivan Gerling; Sarah J Richardson
Journal:  Curr Diab Rep       Date:  2019-12-09       Impact factor: 4.810
  8 in total

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