N C Fox1, P A Freeborough, M N Rossor. 1. Dementia Research Group, National Hospital for Neurology and Neurosurgery, London, UK.
Abstract
BACKGROUND: Definitive diagnosis of Alzheimer's disease requires histological examination of brain tissue. In life, brain atrophy can be visualised by computed tomography or magnetic resonance (MR) imaging, but the atrophy due to the disease is difficult to distinguish from that caused by normal ageing. We have investigated use of accurate positional matching (registration) and digital subtraction of serially acquired MR brain scans to allow determination of rates of global and regional atrophy. METHODS: This technique was applied to eleven patients with clinically diagnosed Alzheimer's disease and eleven age-matched controls. Each individual had two scans approximately 1 year apart; scan intervals were matched between the groups. FINDINGS: The median rate of atrophy was significantly greater in the Alzheimer's disease group than in the control group (12.3 [range 5.8 to 23.6] vs 0.3 (-1.2 to 1.7) mL per year; p < 0.0001). There was no overlap between the groups. Furthermore, three non-demented individuals at risk of familial Alzheimer's disease had scans 6-14 months apart and showed greater rates of volume loss than the controls; these three individuals have subsequently developed symptoms. INTERPRETATION: This technique may be useful for the diagnosis of Alzheimer's disease, the assessment of disease progression, and the evaluation of potential treatments.
BACKGROUND: Definitive diagnosis of Alzheimer's disease requires histological examination of brain tissue. In life, brain atrophy can be visualised by computed tomography or magnetic resonance (MR) imaging, but the atrophy due to the disease is difficult to distinguish from that caused by normal ageing. We have investigated use of accurate positional matching (registration) and digital subtraction of serially acquired MR brain scans to allow determination of rates of global and regional atrophy. METHODS: This technique was applied to eleven patients with clinically diagnosed Alzheimer's disease and eleven age-matched controls. Each individual had two scans approximately 1 year apart; scan intervals were matched between the groups. FINDINGS: The median rate of atrophy was significantly greater in the Alzheimer's disease group than in the control group (12.3 [range 5.8 to 23.6] vs 0.3 (-1.2 to 1.7) mL per year; p < 0.0001). There was no overlap between the groups. Furthermore, three non-demented individuals at risk of familial Alzheimer's disease had scans 6-14 months apart and showed greater rates of volume loss than the controls; these three individuals have subsequently developed symptoms. INTERPRETATION: This technique may be useful for the diagnosis of Alzheimer's disease, the assessment of disease progression, and the evaluation of potential treatments.
Authors: Mert R Sabuncu; Randy L Buckner; Jordan W Smoller; Phil Hyoun Lee; Bruce Fischl; Reisa A Sperling Journal: Cereb Cortex Date: 2011-12-13 Impact factor: 5.357
Authors: C R Jack; M Slomkowski; S Gracon; T M Hoover; J P Felmlee; K Stewart; Y Xu; M Shiung; P C O'Brien; R Cha; D Knopman; R C Petersen Journal: Neurology Date: 2003-01-28 Impact factor: 9.910
Authors: Lei Wang; J Philp Miller; Mokhtar H Gado; Daniel W McKeel; Marcus Rothermich; Michael I Miller; John C Morris; John G Csernansky Journal: Neuroimage Date: 2005-10-21 Impact factor: 6.556
Authors: Paul M Thompson; Kiralee M Hayashi; Greig de Zubicaray; Andrew L Janke; Stephen E Rose; James Semple; David Herman; Michael S Hong; Stephanie S Dittmer; David M Doddrell; Arthur W Toga Journal: J Neurosci Date: 2003-02-01 Impact factor: 6.167
Authors: A T Du; N Schuff; X P Zhu; W J Jagust; B L Miller; B R Reed; J H Kramer; D Mungas; K Yaffe; H C Chui; M W Weiner Journal: Neurology Date: 2003-02-11 Impact factor: 9.910