BACKGROUND: We have investigated the geographic distribution of squamous-cell carcinoma of the eye to assess whether solar ultraviolet light is a risk factor for this disease. METHODS: We used routinely collected population-based cancer incidence data and published measurements of ambient solar ultraviolet light in our analysis. FINDINGS: The incidence of squamous-cell carcinoma of the eye declined by 49% of each 10 degrees increase in latitude (p < 0.0001), falling from more than 12 cases per million per year in Uganda (latitude 0.3(0)) to less than O.2 per million per year in the UK (latitude > 50(0)). Solar ultraviolet radiation decreases with increasing latitude, and the incidence of squamous-cell carcinoma of the eye decreased by 29% per unit reduction in ultraviolet exposure (p < 0.0001). INTERPRETATION: Our results are compatible with the hypothesis that exposure to solar ultraviolet light is an important cause of squamous-cell carcinoma of the eye.
BACKGROUND: We have investigated the geographic distribution of squamous-cell carcinoma of the eye to assess whether solar ultraviolet light is a risk factor for this disease. METHODS: We used routinely collected population-based cancer incidence data and published measurements of ambient solar ultraviolet light in our analysis. FINDINGS: The incidence of squamous-cell carcinoma of the eye declined by 49% of each 10 degrees increase in latitude (p < 0.0001), falling from more than 12 cases per million per year in Uganda (latitude 0.3(0)) to less than O.2 per million per year in the UK (latitude > 50(0)). Solar ultraviolet radiation decreases with increasing latitude, and the incidence of squamous-cell carcinoma of the eye decreased by 29% per unit reduction in ultraviolet exposure (p < 0.0001). INTERPRETATION: Our results are compatible with the hypothesis that exposure to solar ultraviolet light is an important cause of squamous-cell carcinoma of the eye.
Authors: W Tulvatana; P Bhattarakosol; L Sansopha; W Sipiyarak; E Kowitdamrong; T Paisuntornsug; S Karnsawai Journal: Br J Ophthalmol Date: 2003-04 Impact factor: 4.638
Authors: Laura Asnaghi; Hind Alkatan; Alka Mahale; Maha Othman; Saeed Alwadani; Hailah Al-Hussain; Sabah Jastaneiah; Wayne Yu; Azza Maktabi; Deepak P Edward; Charles G Eberhart Journal: Invest Ophthalmol Vis Sci Date: 2014-12-09 Impact factor: 4.799
Authors: M S Spitzer; T Chirambo; P Kayange; P Szurman; E Yoeruek; K U Bartz-Schmidt; H N Batumba Journal: Ophthalmologe Date: 2009-09 Impact factor: 1.059