Literature DB >> 8676457

The hepatitis B virus posttranscriptional regulatory element is composed of two subelements.

J E Donello1, A A Beeche, G J Smith, G R Lucero, T J Hope.   

Abstract

The RNAs of the hepatitis B virus (HBV) contain a cis-acting regulatory element which facilitates the cytoplasmic localization of unspliced transcripts (J. Huang and T. J. Liang, Mol. Cell. Biol. 13:7476-7486, 1993, and Z. M. Huang and T. S. Yen, J. Virl. 68:3193-3199, 1994). Such localization is presumed to be mediated by cellular factors which interact with the element. The HBV posttranscriptional regulatory element (HBVPRE) can efficiently activate an RNA export reporter system in an orientation-dependent and position-independent manner. Deletion analysis reveals that the HBVPRE consists of two subelements which function synergistically. A synergistic effect was also observed when the 5' (PREalpha) or 3' (PREbeta) subelements were duplicated. The bipartite structure of the HBVPRE is reminiscent of reports that the high-affinity binding sites of the Rev-like proteins must be duplicated to function efficiently (M. Grone, E. Hoffmann, S. Berchtold, B.R. Cullen, and R. Grassmann, Virology 204:144-152, 1994; X. Huang, T.J. Hope, B.L. Bond, D. McDonald, K. Grahl, and T. G. Parslow, J. Virol. 65:2131-2134, 1991; and D. McDonald, T. J. Hope, and T. G. Parslow, J. Virol. 66:7232-7238, 1992).

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Year:  1996        PMID： 8676457      PMCID： PMC190367     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  36 in total

1.  Posttranscriptional regulation by the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex proteins through a heterologous RNA binding site.

Authors:  D McDonald; T J Hope; T G Parslow
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

2.  Effector domains of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex are functionally interchangeable and share an essential peptide motif.

Authors:  T J Hope; B L Bond; D McDonald; N P Klein; T G Parslow
Journal:  J Virol       Date:  1991-11       Impact factor: 5.103

3.  Rev and the fate of pre-mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotes.

Authors:  M H Malim; B R Cullen
Journal:  Mol Cell Biol       Date:  1993-10       Impact factor: 4.272

4.  Stimulation of gene expression by introns: conversion of an inhibitory intron to a stimulatory intron by alteration of the splice donor sequence.

Authors:  M Korb; Y Ke; L F Johnson
Journal:  Nucleic Acids Res       Date:  1993-12-25       Impact factor: 16.971

5.  Posttranscriptional effector domains in the Rev proteins of feline immunodeficiency virus and equine infectious anemia virus.

Authors:  V A Mancuso; T J Hope; L Zhu; D Derse; T Phillips; T G Parslow
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

6.  Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production.

Authors:  M L Zapp; S Stern; M R Green
Journal:  Cell       Date:  1993-09-24       Impact factor: 41.582

7.  Viral spliced RNA are produced, encapsidated and reverse transcribed during in vivo woodchuck hepatitis virus infection.

Authors:  O Hantz; I Baginski; I Fourel; I Chemin; C Trepo
Journal:  Virology       Date:  1992-09       Impact factor: 3.616

8.  Human immunodeficiency virus type 1 regulator of virion expression, rev, forms nucleoprotein filaments after binding to a purine-rich "bubble" located within the rev-responsive region of viral mRNAs.

Authors:  S Heaphy; J T Finch; M J Gait; J Karn; M Singh
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-15       Impact factor: 11.205

9.  Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity.

Authors:  D F Purcell; M A Martin
Journal:  J Virol       Date:  1993-11       Impact factor: 5.103

10.  A novel hepatitis B virus (HBV) genetic element with Rev response element-like properties that is essential for expression of HBV gene products.

Authors:  J Huang; T J Liang
Journal:  Mol Cell Biol       Date:  1993-12       Impact factor: 4.272
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  40 in total

1.  Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.

Authors:  R Zufferey; J E Donello; D Trono; T J Hope
Journal:  J Virol       Date:  1999-04       Impact factor: 5.103

2.  Intronless mRNA transport elements may affect multiple steps of pre-mRNA processing.

Authors:  Y Huang; K M Wimler; G G Carmichael
Journal:  EMBO J       Date:  1999-03-15       Impact factor: 11.598

3.  R region sequences in the long terminal repeat of a murine retrovirus specifically increase expression of unspliced RNAs.

Authors:  A M Trubetskoy; S A Okenquist; J Lenz
Journal:  J Virol       Date:  1999-04       Impact factor: 5.103

4.  CRM1-dependent function of a cis-acting RNA export element.

Authors:  Ileana Popa; Matthew E Harris; John E Donello; Thomas J Hope
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

5.  A novel cis-acting element facilitates minus-strand DNA synthesis during reverse transcription of the hepatitis B virus genome.

Authors:  Myeong-Kyun Shin; Jehan Lee; Wang-Shick Ryu
Journal:  J Virol       Date:  2004-06       Impact factor: 5.103

6.  Export of hepatitis B virus RNA on a Rev-like pathway: inhibition by the regenerating liver inhibitory factor IkappaB alpha.

Authors:  J Roth; M Dobbelstein
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

7.  Binding of hnRNP L to the pre-mRNA processing enhancer of the herpes simplex virus thymidine kinase gene enhances both polyadenylation and nucleocytoplasmic export of intronless mRNAs.

Authors:  Shouhong Guang; Alicia M Felthauser; Janet E Mertz
Journal:  Mol Cell Biol       Date:  2005-08       Impact factor: 4.272

8.  The mouse histone H2a gene contains a small element that facilitates cytoplasmic accumulation of intronless gene transcripts and of unspliced HIV-1-related mRNAs.

Authors:  Y Huang; G G Carmichael
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-16       Impact factor: 11.205

9.  A conserved RNA structural element within the hepatitis B virus post-transcriptional regulatory element enhance nuclear export of intronless transcripts and repress the splicing mechanism.

Authors:  Akasit Visootsat; Sunchai Payungporn; Nattanan P T-Thienprasert
Journal:  Mol Biol Rep       Date:  2015-10-29       Impact factor: 2.316

10.  Role of polypyrimidine tract binding protein in the function of the hepatitis B virus posttranscriptional regulatory element.

Authors:  W Q Zang; B Li; P Y Huang; M M Lai; T S Yen
Journal:  J Virol       Date:  2001-11       Impact factor: 5.103
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