Literature DB >> 8675607

ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin.

A Slominski1, G Ermak, M Mihm.   

Abstract

Evidence is provided that mRNA for ACTH (MC-2) receptor and mRNAs for three obligatory enzymes of steroid synthesis including cytochromes P450scc, P450c17 and P450c21 are expressed in normal and pathologic human skin. Thus, molecular elements of the distal loop of the "pituitary-adrenal axis" such as the MC-2, CYP11A1, CYP17 and CYP21A2 genes are expressed in the skin.

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Year:  1996        PMID： 8675607     DOI： 10.1210/jcem.81.7.8675607

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN： 0021-972X            Impact factor:   5.958


  57 in total

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Review 9.  The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions.

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