Literature DB >> 8674195

Long-term stability of blood glutathione and cysteine in humans.

J P Richie1, P Abraham, Y Leutzinger.   

Abstract

Glutathione (GSH) availability is an important factor in the maintenance of health. Accordingly, blood GSH has been proposed as an indicator of health status. To validate the use of blood GSH in population studies, we investigated the long-term intraindividual variation of blood GSH and cyst(e)ine (Cys and cystine) concentrations in healthy adults. In a longitudinal study of 10 subjects, GSH and cyst(e)ine were measured in blood samples collected weekly over 8 months. The average within-person CV for GSH was only 9.1% compared with an observed interindividual CV of 20%. Blood cyst(e)ine was more variable within individuals (mean CV 14.7%) than GSH, whereas the interindividual CV for cyst(e)ine was lower (8.6%). The results demonstrate the stability of blood GSH in free-living subjects and the utility of GSH measurements as an indicator of long-term GSH status.

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Year:  1996        PMID： 8674195

Source DB:  PubMed          Journal:  Clin Chem        ISSN： 0009-9147            Impact factor:   8.327


  7 in total

1.  Metabolomics of ADSOL (AS-1) red blood cell storage.

Authors:  John D Roback; Cassandra D Josephson; Edmund K Waller; James L Newman; Sulaiman Karatela; Karan Uppal; Dean P Jones; James C Zimring; Larry J Dumont
Journal:  Transfus Med Rev       Date:  2014-02-05

2.  Glutathione synthesis and turnover in the human erythrocyte: alignment of a model based on detailed enzyme kinetics with experimental data.

Authors:  Julia E Raftos; Stephney Whillier; Philip W Kuchel
Journal:  J Biol Chem       Date:  2010-05-24       Impact factor: 5.157

3.  Experimental colitis and malnutrition differentially affect the metabolism of glutathione and related sulfhydryl metabolites in different tissues.

Authors:  Photios Vassilyadi; Scott V Harding; Evan Nitschmann; Linda J Wykes
Journal:  Eur J Nutr       Date:  2015-07-25       Impact factor: 5.614

4.  Blood iron, glutathione, and micronutrient levels and the risk of oral cancer.

Authors:  John P Richie; Wayne Kleinman; Patricia Marina; Patricia Abraham; Ernst L Wynder; Joshua E Muscat
Journal:  Nutr Cancer       Date:  2008       Impact factor: 2.900

5.  The concentration of glutathione in human erythrocytes is a heritable trait.

Authors:  Thomas J van 't Erve; Brett A Wagner; Kelli K Ryckman; Thomas J Raife; Garry R Buettner
Journal:  Free Radic Biol Med       Date:  2013-08-09       Impact factor: 7.376

6.  Chronic arsenic exposure and blood glutathione and glutathione disulfide concentrations in Bangladeshi adults.

Authors:  Megan N Hall; Megan Niedzwiecki; Xinhua Liu; Kristin N Harper; Shafiul Alam; Vesna Slavkovich; Vesna Ilievski; Diane Levy; Abu B Siddique; Faruque Parvez; Jacob L Mey; Alexander van Geen; Joseph Graziano; Mary V Gamble
Journal:  Environ Health Perspect       Date:  2013-06-21       Impact factor: 9.031

7.  Association Between Socio-Affective Symptoms and Glutathione and CD4 and CD8 Lymphocytes in College Students.

Authors:  Cecilia Luz Balderas-Vazquez; Blandina Bernal-Morales; Eliud Alfredo Garcia-Montalvo; Libia Vega; Emma Virginia Herrera-Huerta; Juan Francisco Rodríguez-Landa; José Felipe Velázquez-Hernández; María Del Carmen Xotlanihua-Gervacio; Olga Lidia Valenzuela
Journal:  Front Psychol       Date:  2022-01-05
  7 in total

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