Literature DB >> 8674183

Metabolism of anabolic androgenic steroids.

W Schänzer1.   

Abstract

Anabolic androgenic steroids (AAS) are misused to a high extent in sports by athletes to improve their physical performance. Sports federations consider the use of these drugs in sports as doping. The misuse of AAS is controlled by detection of the parent AAS (when excreted into urine) and (or) their metabolites in urine of athletes. I present a review of the metabolism of AAS. Testosterone is the principal androgenic steroid and its metabolism is compared with that of AAS. The review is divided into two parts: the general metabolism of AAS, which is separated into phase I and phase II metabolism and includes a systematic discussion of metabolic changes in the steroid molecule according to the regions (A-D rings), and the specific metabolism of AAS, which presents the metabolism of 26 AAS in humans.

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Year:  1996        PMID： 8674183

Source DB:  PubMed          Journal:  Clin Chem        ISSN： 0009-9147            Impact factor:   8.327


  30 in total

1.  Determination of testosterone and its photodegradation products in surface waters using solid-phase extraction followed by LC-MS/MS analysis.

Authors:  Emmanuelle Vulliet; Barbara Giroud; Pedro Marote
Journal:  Environ Sci Pollut Res Int       Date:  2012-06-24       Impact factor: 4.223

Review 2.  Significance of 19-norandrosterone in athletes' urine samples.

Authors:  C Ayotte
Journal:  Br J Sports Med       Date:  2006-07       Impact factor: 13.800

3.  Cardiac autonomic dysfunction in rats chronically treated with anabolic steroid.

Authors:  Pedro P Pereira-Junior; Elen A Chaves; Ricardo H Costa-E-Sousa; Masako O Masuda; Antonio C Campos de Carvalho; José H M Nascimento
Journal:  Eur J Appl Physiol       Date:  2005-12-13       Impact factor: 3.078

4.  Investigation of vitamin B₆ inadequacy, induced by exposure to the anti-B₆ factor 1-amino D-proline, on plasma lipophilic metabolites of rats: a metabolomics approach.

Authors:  Shyamchand Mayengbam; James D House; Michel Aliani
Journal:  Eur J Nutr       Date:  2015-05-26       Impact factor: 5.614

Review 5.  Adverse health consequences of performance-enhancing drugs: an Endocrine Society scientific statement.

Authors:  Harrison G Pope; Ruth I Wood; Alan Rogol; Fred Nyberg; Larry Bowers; Shalender Bhasin
Journal:  Endocr Rev       Date:  2013-12-17       Impact factor: 19.871

Review 6.  The androgen receptor and its use in biological assays: looking toward effect-based testing and its applications.

Authors:  Amy B Cadwallader; Carol S Lim; Douglas E Rollins; Francesco Botrè
Journal:  J Anal Toxicol       Date:  2011-11       Impact factor: 3.367

Review 7.  Anabolic androgenic steroid abuse: multiple mechanisms of regulation of GABAergic synapses in neuroendocrine control regions of the rodent forebrain.

Authors:  J G Oberlander; D M Porter; C A A Penatti; L P Henderson
Journal:  J Neuroendocrinol       Date:  2012-01       Impact factor: 3.627

8.  Potentially harmful advantage to athletes: a putative connection between UGT2B17 gene deletion polymorphism and renal disorders with prolonged use of anabolic androgenic steroids.

Authors:  Nawed Deshmukh; Andrea Petróczi; James Barker; Andrea D Székely; Iltaf Hussain; Declan P Naughton
Journal:  Subst Abuse Treat Prev Policy       Date:  2010-04-29

Review 9.  Analysis of conjugated steroid androgens: deconjugation, derivatisation and associated issues.

Authors:  Rachel L Gomes; Will Meredith; Colin E Snape; Mark A Sephton
Journal:  J Pharm Biomed Anal       Date:  2009-01-31       Impact factor: 3.935

10.  Gene expression in hair follicle dermal papilla cells after treatment with stanozolol.

Authors:  M Reiter; M W Pfaffl; M Schönfelder; H H D Meyer
Journal:  Biomark Insights       Date:  2008-12-23
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