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Literature DB >> 8672127

Genetic mapping of the human and mouse phospholipase C genes.

M S Lyu¹, D J Park, S G Rhee, C A Kozak.

Abstract

To determine chromosome positions for 10 mouse phospholipase C (PLC) genes, we typed the progeny of two sets of genetic crosses for inheritance of restriction enzyme polymorphisms of each PLC. Four mouse chromosomes, Chr 1, 11, 12, and 19, contained single PLC genes. Four PLC loci, Plcb1, Plcb2, Plcb4, and Plcg1, mapped to three sites on distal mouse Chr 2. Two PLC genes, Plcd1 and Plcg2, mapped to distinct sites on Chr 8. We mapped the human homologs of eight of these genes to six chromosomes by analysis of human x rodent somatic cell hybrids. The map locations of seven of these genes were consistent with previously defined regions of conserved synteny; Plcd1 defines a new region of homology between human Chr 3 and mouse Chr 8.

Entities: Gene Species

Mesh：

Substances：

Year: 1996 PMID： 8672127 DOI： 10.1007/s003359900151

Source DB: PubMed Journal: Mamm Genome ISSN： 0938-8990 Impact factor: 2.957

44 in total

1. Localization of phospholipase C-gamma 1 to mouse chromosome 2.

Authors: K K Nelson; J L Knopf; L D Siracusa
Journal: Mamm Genome Date: 1992 Impact factor: 2.957

2. A microsatellite polymorphism associated with the PLC1 (phospholipase C) locus: identification, mapping, and linkage to the MODY locus on chromosome 20.

Authors: C B Rothschild; G Akots; S S Fajans; D W Bowden
Journal: Genomics Date: 1992-07 Impact factor: 5.736

3. Mouse ferritin H multigene family is polymorphic and contains a single multiallelic functional gene located on chromosome 19.

Authors: A K Yachou; F Renaudie; J L Guenet; D Simon-Chazottes; R Jones; B Grandchamp; C Beaumont
Journal: Genomics Date: 1991-07 Impact factor: 5.736

Review 4. Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes.

Authors: S B Lee; S G Rhee
Journal: Curr Opin Cell Biol Date: 1995-04 Impact factor: 8.382

5. Genetic mapping of tumor susceptibility genes involved in mouse plasmacytomagenesis.

Authors: B A Mock; M M Krall; J K Dosik
Journal: Proc Natl Acad Sci U S A Date: 1993-10-15 Impact factor: 11.205

6. Genomic cloning of mouse MIF (macrophage inhibitory factor) and genetic mapping of the human and mouse expressed gene and nine mouse pseudogenes.

Authors: C A Kozak; M C Adamson; C E Buckler; L Segovia; V Paralkar; G Wistow
Journal: Genomics Date: 1995-06-10 Impact factor: 5.736

7. Phosphoinositide signaling in nuclei of Friend cells: phospholipase C beta down-regulation is related to cell differentiation.

Authors: A M Martelli; A M Billi; R S Gilmour; L M Neri; L Manzoli; A Ognibene; L Cocco
Journal: Cancer Res Date: 1994-05-15 Impact factor: 12.701

Genetic mapping of the human and mouse phospholipase C genes.

1. Localization of phospholipase C-gamma 1 to mouse chromosome 2.

2. A microsatellite polymorphism associated with the PLC1 (phospholipase C) locus: identification, mapping, and linkage to the MODY locus on chromosome 20.

3. Mouse ferritin H multigene family is polymorphic and contains a single multiallelic functional gene located on chromosome 19.

Review 4. Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes.

5. Genetic mapping of tumor susceptibility genes involved in mouse plasmacytomagenesis.

6. Genomic cloning of mouse MIF (macrophage inhibitory factor) and genetic mapping of the human and mouse expressed gene and nine mouse pseudogenes.

7. Phosphoinositide signaling in nuclei of Friend cells: phospholipase C beta down-regulation is related to cell differentiation.

8. Cloning, sequencing, purification, and Gq-dependent activation of phospholipase C-beta 3.

9. Localization of the murine Hmg1 gene, encoding an HMG-box protein, to mouse chromosome 2.

10. cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4).

1. A phenotype-based screen for embryonic lethal mutations in the mouse.

2. Endogenous human microRNAs that suppress breast cancer metastasis.

3. Distinct Prognostic Values of Phospholipase C Beta Family Members for Non-Small Cell Lung Carcinoma.