| Literature DB >> 8670339 |
R J McKendry1, L Huebsch, B Leclair.
Abstract
The progression of rheumatoid arthritis (RA) is documented in a patient receiving a sex-mismatched, allogeneic bone marrow transplant (BMT) for gold-induced marrow aplasia. DNA typing confirmed a high probability of a full donor engraftment (complete chimerism). Although the RA was in complete remission 2 years post-BMT, clinical, laboratory, histologic, and radiologic evidence of the recurrence of synovitis from 3-13 years post-BMT is presented. Implications of these observations for theories of the pathogenesis of RA and the future of immunotherapies are discussed.Entities:
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Year: 1996 PMID： 8670339 DOI： 10.1002/art.1780390727
Source DB: PubMed Journal: Arthritis Rheum ISSN： 0004-3591