Literature DB >> 8670303

Cloning and tissue distribution of a novel P2X receptor from rat brain.

F Soto1, M Garcia-Guzman, C Karschin, W Stühmer.   

Abstract

We have isolated the cDNA for a novel member (P2X6) of the ATP-gated ion channel family. The rat P2X6 nucleotide sequence encodes a 379 amino acid protein that conserves all the structural features of previously cloned P2X receptors, including the two putative transmembrane domains predicted by hydrophobicity plots. In situ hybridization analysis of rat brain sections showed a wide pattern of mRNA expression that is virtually identical to that already described for P2X4. Injection of P2X6 cRNA in Xenopus oocytes did not give rise to ATP-activated channels. Coexpression of P2X6 with P2X4 subunits produced currents which were not discernibly different from those of P2X4 expressed alone.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8670303     DOI： 10.1006/bbrc.1996.0915

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  27 in total

Review 1.  Molecular and functional properties of P2X receptors--recent progress and persisting challenges.

Authors:  Karina Kaczmarek-Hájek; Eva Lörinczi; Ralf Hausmann; Annette Nicke
Journal:  Purinergic Signal       Date:  2012-05-01       Impact factor: 3.765

2.  Distinct Localization of P2X receptors at excitatory postsynaptic specializations.

Authors:  M E Rubio; F Soto
Journal:  J Neurosci       Date:  2001-01-15       Impact factor: 6.167

Review 3.  Determination of the architecture of ionotropic receptors using AFM imaging.

Authors:  Nelson P Barrera; Robert M Henderson; J Michael Edwardson
Journal:  Pflugers Arch       Date:  2007-11-17       Impact factor: 3.657

4.  Functional expression of P2X4 receptor in capillary endothelial cells of the cochlear spiral ligament and its role in regulating the capillary diameter.

Authors:  T Wu; M Dai; X R Shi; Z G Jiang; A L Nuttall
Journal:  Am J Physiol Heart Circ Physiol       Date:  2011-04-01       Impact factor: 4.733

Review 5.  Implication of the purinergic system in alcohol use disorders.

Authors:  Liana Asatryan; Hyung W Nam; Moonnoh R Lee; Mahesh M Thakkar; M Saeed Dar; Daryl L Davies; Doo-Sup Choi
Journal:  Alcohol Clin Exp Res       Date:  2011-01-11       Impact factor: 3.455

6.  Extracellular ATP directly gates a cation-selective channel in rabbit airway ciliated epithelial cells.

Authors:  A Korngreen; W Ma; Z Priel; S D Silberberg
Journal:  J Physiol       Date:  1998-05-01       Impact factor: 5.182

Review 7.  Nucleotide receptors in the nervous system. An abundant component using diverse transduction mechanisms.

Authors:  E A Barnard; J Simon; T E Webb
Journal:  Mol Neurobiol       Date:  1997-10       Impact factor: 5.590

8.  ATP binding site mutagenesis reveals different subunit stoichiometry of functional P2X2/3 and P2X2/6 receptors.

Authors:  Ralf Hausmann; Mandy Bodnar; Ronja Woltersdorf; Haihong Wang; Martin Fuchs; Nanette Messemer; Ying Qin; Janka Günther; Thomas Riedel; Marcus Grohmann; Karen Nieber; Günther Schmalzing; Patrizia Rubini; Peter Illes
Journal:  J Biol Chem       Date:  2012-02-29       Impact factor: 5.157

9.  Inhibiting the P2X4 Receptor Suppresses Prostate Cancer Growth In Vitro and In Vivo, Suggesting a Potential Clinical Target.

Authors:  Jiepei He; Yuhan Zhou; Hector M Arredondo Carrera; Alexandria Sprules; Ramona Neagu; Sayyed Amin Zarkesh; Colby Eaton; Jian Luo; Alison Gartland; Ning Wang
Journal:  Cells       Date:  2020-11-20       Impact factor: 6.600

Review 10.  Implication of Neuronal Versus Microglial P2X4 Receptors in Central Nervous System Disorders.

Authors:  Alexia Duveau; Eléonore Bertin; Eric Boué-Grabot
Journal:  Neurosci Bull       Date:  2020-09-05       Impact factor: 5.203
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.