Literature DB >> 8670291

6-Bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids.

M Marder1, H Viola, C Wasowski, C Wolfman, P G Waterman, B K Cassels, J G Medina, A C Paladini.   

Abstract

6-Bromoflavone, obtained by bromination of flavanone, binds to central benzodiazepine receptors with a Ki=70 nM and has a clear anxiolytic activity in mice, at 0.5 mg/kg i.p. A survey of the structure/affinity relationship for those receptors in a series of natural and synthetic flavonoids is presented.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8670291     DOI： 10.1006/bbrc.1996.0903

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

Review 1.  Overview--flavonoids: a new family of benzodiazepine receptor ligands.

Authors:  J H Medina; H Viola; C Wolfman; M Marder; C Wasowski; D Calvo; A C Paladini
Journal:  Neurochem Res       Date:  1997-04       Impact factor: 3.996

2.  Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor.

Authors:  Suengmok Cho; Minseok Yoon; Ae Nim Pae; Young-Ho Jin; Nam-Chul Cho; Yohko Takata; Yoshihiro Urade; Sojin Kim; Jin-Soo Kim; Hyejin Yang; Jiyoung Kim; Jinkyoung Kim; Jin-Kyu Han; Makoto Shimizu; Zhi-Li Huang
Journal:  Psychopharmacology (Berl)       Date:  2014-02-01       Impact factor: 4.530

Review 3.  Flavonoid modulation of GABA(A) receptors.

Authors:  Jane R Hanrahan; Mary Chebib; Graham A R Johnston
Journal:  Br J Pharmacol       Date:  2011-05       Impact factor: 8.739

4.  Chemical composition and anxiolytic evaluation of Achillea Wilhelmsii C. Koch essential oil in rat.

Authors:  M B Majnooni; A Mohammadi-Farani; M B Gholivand; M R Nikbakht; G R Bahrami
Journal:  Res Pharm Sci       Date:  2013-10

5.  Comparison of Elaeagnus angustifolia Extract and Sildenafil Citrate on Female Orgasmic Disorders: A Randomized Clinical Trial.

Authors:  Marzieh Akbarzadeh; Sanaz Zeinalzadeh; Jaleh Zolghadri; Abdolali Mohagheghzadeh; Pouya Faridi; Mehrab Sayadi
Journal:  J Reprod Infertil       Date:  2014-10

6.  Evaluation of the anxiolytic effect of Nepeta persica Boiss. in mice.

Authors:  M Rabbani; S E Sajjadi; A Mohammadi
Journal:  Evid Based Complement Alternat Med       Date:  2008-06       Impact factor: 2.629

7.  Flavones from Erythrina falcata are modulators of fear memory.

Authors:  Daniela Rodrigues de Oliveira; Cláudia R Zamberlam; Renan Barreta Gaiardo; Gizelda Maia Rêgo; Janete M Cerutti; Alberto J Cavalheiro; Suzete M Cerutti
Journal:  BMC Complement Altern Med       Date:  2014-08-05       Impact factor: 3.659

Review 8.  Flavonoids as GABAA receptor ligands: the whole story?

Authors:  Cristina Wasowski; Mariel Marder
Journal:  J Exp Pharmacol       Date:  2012-02-23

9.  Differential Effects of Quercetin and Quercetin Glycosides on Human α7 Nicotinic Acetylcholine Receptor-Mediated Ion Currents.

Authors:  Byung-Hwan Lee; Sun-Hye Choi; Hyeon-Joong Kim; Seok-Won Jung; Sung-Hee Hwang; Mi-Kyung Pyo; Hyewhon Rhim; Hyoung-Chun Kim; Ho-Kyoung Kim; Sang-Mok Lee; Seung-Yeol Nah
Journal:  Biomol Ther (Seoul)       Date:  2016-04-25       Impact factor: 4.634
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.