Literature DB >> 8670280

A protein AA-variant derived from a novel serum AA protein, SAA1 delta, in an individual from Papua New Guinea.

P Westermark1, K Sletten, G T Westermark, J Raynes, K P McAdam.   

Abstract

A major protein AA amyloid protein was purified and characterised from a Papua New Guinnean individual. This AA protein differed from all previously characterised SAA variants by the combination of Ala52, Val57, Asn60, Phe68, Phe69 and Gly72. Since the prevalence of AA-amyloidosis is unusually high in Papua New Guinea this AAdelta must originate from a novel SAAdelta which may represent a particularly amyloidogenic variant.

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Year:  1996        PMID: 8670280     DOI: 10.1006/bbrc.1996.0892

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN: 0006-291X            Impact factor:   3.575


  2 in total

1.  Acceleration of amyloid protein A amyloidosis by amyloid-like synthetic fibrils.

Authors:  K Johan; G Westermark; U Engström; A Gustavsson; P Hultman; P Westermark
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-03       Impact factor: 11.205

Review 2.  Review. Reflections on amyloidosis in Papua New Guinea.

Authors:  Per Westermark; Gunilla T Westermark
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2008-11-27       Impact factor: 6.237

  2 in total

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