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Literature DB >> 8670047

Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin.

D B Reardon¹, S L Wood, D L Brautigan, G I Bell, P Dent, T W Sturgill.

Abstract

Human somatostatin receptor 3 ('hsstr3') was transiently expressed in NIH 3T3 cells stably transformed with Ha-Ras (G12V). Somatostatin activated a protein tyrosine phosphatase and inactivated the constitutively active, membrane-associated form of the Raf-1 serine kinase present in these cells in vivo and in vitro.

Entities: Gene Mutation Species

Mesh：

Substances：

Year: 1996 PMID： 8670047 PMCID： PMC1217062 DOI： 10.1042/bj3140401

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

22 in total

1. Preferential inhibition of the oncogenic form of RasH by mutations in the GAP binding/"effector" domain.

Authors: C L Farnsworth; M S Marshall; J B Gibbs; D W Stacey; L A Feig
Journal: Cell Date: 1991-02-08 Impact factor: 41.582

2. Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.

Authors: J Alblas; E J van Corven; P L Hordijk; G Milligan; W H Moolenaar
Journal: J Biol Chem Date: 1993-10-25 Impact factor: 5.157

3. Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.

Authors: S Traverse; P Cohen; H Paterson; C Marshall; U Rapp; R J Grand
Journal: Oncogene Date: 1993-11 Impact factor: 9.867

4. Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

Authors: P Crespo; N Xu; W F Simonds; J S Gutkind
Journal: Nature Date: 1994-06-02 Impact factor: 49.962

Review 5. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.

Authors: C J Marshall
Journal: Curr Opin Genet Dev Date: 1994-02 Impact factor: 5.578

6. G protein activation of a hormone-stimulated phosphatase in human tumor cells.

Authors: M G Pan; T Florio; P J Stork
Journal: Science Date: 1992-05-22 Impact factor: 47.728

7. Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade.

Authors: H Bito; M Mori; C Sakanaka; T Takano; Z Honda; Y Gotoh; E Nishida; T Shimizu
Journal: J Biol Chem Date: 1994-04-29 Impact factor: 5.157

8. Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase.

Authors: K Yasuda; S Rens-Domiano; C D Breder; S F Law; C B Saper; T Reisine; G I Bell
Journal: J Biol Chem Date: 1992-10-05 Impact factor: 5.157

9. Serine phosphorylation of protein tyrosine phosphatase (PTP1B) in HeLa cells in response to analogues of cAMP or diacylglycerol plus okadaic acid.

Authors: D L Brautigan; F M Pinault
Journal: Mol Cell Biochem Date: 1993-11 Impact factor: 3.396

Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin.

1. Preferential inhibition of the oncogenic form of RasH by mutations in the GAP binding/"effector" domain.

2. Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.

3. Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.

4. Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

Review 5. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.

6. G protein activation of a hormone-stimulated phosphatase in human tumor cells.

7. Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade.

8. Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase.

9. Serine phosphorylation of protein tyrosine phosphatase (PTP1B) in HeLa cells in response to analogues of cAMP or diacylglycerol plus okadaic acid.

10. Stimulation of a membrane tyrosine phosphatase activity by somatostatin analogues in rat pancreatic acinar cells.

1. SST3-selective potent peptidic somatostatin receptor antagonists.

2. Somatostatin inhibits colon cancer cell growth through cyclooxygenase-2 downregulation.

Review 3. Molecular pharmacology of somatostatin receptor subtypes.

Review 4. Somatostatin and somatostatin receptor physiology.

Review 5. Somatostatin receptor biology in neuroendocrine and pituitary tumours: part 1--molecular pathways.