PURPOSE: To determine the natural history of intracranial calcifications in infants with treated congenital toxoplasmosis. MATERIALS AND METHODS: Between January 1982 and March 1994, cranial computed tomography was performed in 56 infants with treated congenital toxoplasmosis when they were newborns and approximately 1 year old. Locations and sizes of intracranial calcifications were noted. RESULTS: Forty newborns had intracranial calcifications. By 1 year of age, calcifications diminished or resolved in 30 (75%) and remained stable in 10 (25%) of these treated infants. Ten (33%) of the 30 infants whose calcifications diminished versus seven (70%) of the 10 infants with stable calcifications received less intensive antimicrobial treatment than the other treated infants. In contrast, a small number of infants who were untreated or treated 1 month or less had intracranial calcifications that increased or remained stable during their 1st year of life. CONCLUSION: Diminution or resolution of intracranial calcifications was an unexpected and remarkable finding in infants with treated, congenital toxoplasmosis, consonant with their improved neurologic functioning.
PURPOSE: To determine the natural history of intracranial calcifications in infants with treated congenital toxoplasmosis. MATERIALS AND METHODS: Between January 1982 and March 1994, cranial computed tomography was performed in 56 infants with treated congenital toxoplasmosis when they were newborns and approximately 1 year old. Locations and sizes of intracranial calcifications were noted. RESULTS: Forty newborns had intracranial calcifications. By 1 year of age, calcifications diminished or resolved in 30 (75%) and remained stable in 10 (25%) of these treated infants. Ten (33%) of the 30 infants whose calcifications diminished versus seven (70%) of the 10 infants with stable calcifications received less intensive antimicrobial treatment than the other treated infants. In contrast, a small number of infants who were untreated or treated 1 month or less had intracranial calcifications that increased or remained stable during their 1st year of life. CONCLUSION: Diminution or resolution of intracranial calcifications was an unexpected and remarkable finding in infants with treated, congenital toxoplasmosis, consonant with their improved neurologic functioning.
Authors: Samantha R Béla; Míriam S Dutra; Ernest Mui; Alexandre Montpetit; Fernanda S Oliveira; Sérgio C Oliveira; Rosa M E Arantes; Lis R Antonelli; Rima McLeod; Ricardo T Gazzinelli Journal: Infect Immun Date: 2012-10-01 Impact factor: 3.441
Authors: Kenneth Boyer; Dolores Hill; Ernest Mui; Kristen Wroblewski; Theodore Karrison; J P Dubey; Mari Sautter; A Gwendolyn Noble; Shawn Withers; Charles Swisher; Peter Heydemann; Tiffany Hosten; Jane Babiarz; Daniel Lee; Paul Meier; Rima McLeod Journal: Clin Infect Dis Date: 2011-10-21 Impact factor: 9.079
Authors: Rima McLeod; Kenneth M Boyer; Daniel Lee; Ernest Mui; Kristen Wroblewski; Theodore Karrison; A Gwendolyn Noble; Shawn Withers; Charles N Swisher; Peter T Heydemann; Mari Sautter; Jane Babiarz; Peter Rabiah; Paul Meier; Michael E Grigg Journal: Clin Infect Dis Date: 2012-04-11 Impact factor: 9.079
Authors: A Gwendolyn Noble; Paul Latkany; Jaroslaw Kusmierczyk; Marilyn Mets; Peter Rabiah; Kenneth Boyer; Jessica Jalbrzikowski; Kristen Wroblewski; Theodore Karrison; Charles N Swisher; William F Mieler; Paul Meier; Rima McLeod Journal: Sci Med (Porto Alegre) Date: 2010