[The effect of ethanol-applications on uric acid-metabolism in minipigs (author's transl)].

The effect of several drugs on minipigs was examined over a period of upto 3 months. The drugs applied were: ethanol, etacryn acid (per os), ethanol, maleic acid, physiological NaCl--solution (by infusion). The creatinin-, uric acid-, lactat- and haematocrit-values of the serum and blood as well as the creatinin- and uric-excretion were followed. For ethanol and maleine acid an increase of the creatinin- and uric acid-excretion was found. This was accompanied by an increase of the haematocrit value. If the diuresis was augmented by certain substances, a more or less pronounced uricosuria was found. The measured values will be discussed, especially how the renal function may be involved.