Literature DB >> 8667616

Growth factors in the regenerating pancreas of gamma-interferon transgenic mice.

M Arnush1, D Gu, C Baugh, S P Sawyer, B Mroczkowski, T Krahl, N Sarvetnick.   

Abstract

We examined the distribution of several relevant growth factors in gamma-interferon transgenic mice, which undergo continual growth and differentiation in the pancreas. As a result, epidermal growth factor (EGF), TGF-alpha, and the EGF receptor were identified as potentially important in mediating some of these regenerative changes. Transient up-regulation of EGF, TGF-alpha, and the EGF receptor were observed in acini undergoing differentiation into duct-like structures. These ducts have been shown to proliferate and potentiate regeneration of the pancreatic islet mass.

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Year:  1996        PMID： 8667616

Source DB:  PubMed          Journal:  Lab Invest        ISSN： 0023-6837            Impact factor:   5.662


  7 in total

Review 1.  Facilitating physiologic self-regeneration: a step beyond islet cell replacement.

Authors:  Pleunie P M Rood; Rita Bottino; A N Balamurugan; Yong Fan; David K C Cooper; Massimo Trucco
Journal:  Pharm Res       Date:  2006-01-01       Impact factor: 4.200

2.  Expression and function of leukaemia inhibitory factor and its receptor in normal and regenerating rat pancreas.

Authors:  S De Breuck; L Baeyens; L Bouwens
Journal:  Diabetologia       Date:  2005-12-21       Impact factor: 10.122

Review 3.  Regeneration of the pancreatic beta cell.

Authors:  Massimo Trucco
Journal:  J Clin Invest       Date:  2005-01       Impact factor: 14.808

4.  Pancreatic expression of keratinocyte growth factor leads to differentiation of islet hepatocytes and proliferation of duct cells.

Authors:  M L Krakowski; M R Kritzik; E M Jones; T Krahl; J Lee; M Arnush; D Gu; N Sarvetnick
Journal:  Am J Pathol       Date:  1999-03       Impact factor: 4.307

Review 5.  Molecular signaling in pancreatic ductal metaplasia: emerging biomarkers for detection and intervention of early pancreatic cancer.

Authors:  Xiaojia Li; Jie He; Keping Xie
Journal:  Cell Oncol (Dordr)       Date:  2022-03-15       Impact factor: 6.730

6.  Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan.

Authors:  I Rooman; L Bouwens
Journal:  Diabetologia       Date:  2003-12-10       Impact factor: 10.122

7.  Dexamethasone treatment induces the reprogramming of pancreatic acinar cells to hepatocytes and ductal cells.

Authors:  Amani Al-Adsani; Zoë D Burke; Daniel Eberhard; Katherine L Lawrence; Chia-Ning Shen; Anil K Rustgi; Hiroshi Sakaue; J Mark Farrant; David Tosh
Journal:  PLoS One       Date:  2010-10-27       Impact factor: 3.240
  7 in total

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