Literature DB >> 8666290

Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor.

C Léon1, C Vial, J P Cazenave, C Gachet.   

Abstract

We have cloned and sequenced a 3055-bp human placenta cDNA encoding a P2 purinoceptor. An identical receptor has also been found in human saphenous vein endothelial cells. Comparison of the deduced amino acid (aa) sequence to those of previously described P2Y1 purinoceptors revealed greater than 95% aa identity with the rat and mouse counterparts, and 83% with the chick P2Y1 purinoceptor. Northern blot experiments revealed two mRNAs of 7.5 and 4.6 kb whose expression varies according to the tissue examined.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8666290     DOI： 10.1016/0378-1119(96)00027-3

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  13 in total

1.  [32P]2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([32P]MRS2500), a novel radioligand for quantification of native P2Y1 receptors.

Authors:  Dayle Houston; Michihiro Ohno; Robert A Nicholas; Kenneth A Jacobson; T Kendall Harden
Journal:  Br J Pharmacol       Date:  2006-03       Impact factor: 8.739

Review 2.  International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy.

Authors:  Maria P Abbracchio; Geoffrey Burnstock; Jean-Marie Boeynaems; Eric A Barnard; José L Boyer; Charles Kennedy; Gillian E Knight; Marta Fumagalli; Christian Gachet; Kenneth A Jacobson; Gary A Weisman
Journal:  Pharmacol Rev       Date:  2006-09       Impact factor: 25.468

Review 3.  P2 receptor subtypes in the cardiovascular system.

Authors:  S P Kunapuli; J L Daniel
Journal:  Biochem J       Date:  1998-12-15       Impact factor: 3.857

4.  Single nucleotide polymorphisms of the purinergic 1 receptor are not associated with myocardial infarction in a Latvian population.

Authors:  Vita Ignatovica; Gustavs Latkovskis; Raitis Peculis; Kaspars Megnis; Helgi B Schioth; Iveta Vaivade; Davids Fridmanis; Valdis Pirags; Andrejs Erglis; Janis Klovins
Journal:  Mol Biol Rep       Date:  2011-06-04       Impact factor: 2.316

Review 5.  Nucleotide receptors in the nervous system. An abundant component using diverse transduction mechanisms.

Authors:  E A Barnard; J Simon; T E Webb
Journal:  Mol Neurobiol       Date:  1997-10       Impact factor: 5.590

6.  The P2Y purinoceptor in rat brain microvascular endothelial cells couple to inhibition of adenylate cyclase.

Authors:  T E Webb; E Feolde; P Vigne; J T Neary; A Runberg; C Frelin; E A Barnard
Journal:  Br J Pharmacol       Date:  1996-12       Impact factor: 8.739

7.  Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs.

Authors:  C J Foster; D M Prosser; J M Agans; Y Zhai; M D Smith; J E Lachowicz; F L Zhang; E Gustafson; F J Monsma; M T Wiekowski; S J Abbondanzo; D N Cook; M L Bayne; S A Lira; M S Chintala
Journal:  J Clin Invest       Date:  2001-06       Impact factor: 14.808

Review 8.  Identification, characterization, and inhibition of the platelet ADP receptors.

Authors:  C Gachet
Journal:  Int J Hematol       Date:  2001-12       Impact factor: 2.490

9.  Extracellular ATP inhibits chloride channels in mature mammalian skeletal muscle by activating P2Y1 receptors.

Authors:  Andrew A Voss
Journal:  J Physiol       Date:  2009-10-05       Impact factor: 5.182

10.  P2RY1 and P2RY12 polymorphisms and on-aspirin platelet reactivity in patients with coronary artery disease.

Authors:  A A Timur; G Murugesan; L Zhang; P P Aung; J Barnard; Q K Wang; P Gaussem; R L Silverstein; D L Bhatt; K Kottke-Marchant
Journal:  Int J Lab Hematol       Date:  2012-05-10       Impact factor: 2.877
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.