Literature DB >> 8664547

The role of BSAP (Pax-5) in B-cell development.

M Busslinger1, P Urbánek.   

Abstract

The hierarchy of transcriptional control in B-cell development has recently been analyzed by targeted gene inactivation in the mouse. In this manner, the paired box containing gene Pax-5, encoding the B cell specific transcription factor BSAP, has been shown to play a key role in early B lymphopoiesis. Other experimental strategies have implicated BSAP in the control of cell proliferation, isotype switching and transcription of the immunoglobulin heavy-chain gene at late stages of B-cell differentiation.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 8664547     DOI： 10.1016/0959-437x(95)80028-x

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  11 in total

1.  Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding.

Authors:  E C Roberts; R W Deed; T Inoue; J D Norton; A D Sharrocks
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

2.  Activation of the early B-cell-specific mb-1 (Ig-alpha) gene by Pax-5 is dependent on an unmethylated Ets binding site.

Authors:  Holly Maier; Jeff Colbert; Daniel Fitzsimmons; Dawn R Clark; James Hagman
Journal:  Mol Cell Biol       Date:  2003-03       Impact factor: 4.272

3.  Deregulation of PAX-5 by translocation of the Emu enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma.

Authors:  M Busslinger; N Klix; P Pfeffer; P G Graninger; Z Kozmik
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-11       Impact factor: 11.205

4.  Distinct factors regulate the murine RAG-2 promoter in B- and T-cell lines.

Authors:  J Lauring; M S Schlissel
Journal:  Mol Cell Biol       Date:  1999-04       Impact factor: 4.272

5.  The highly conserved beta-hairpin of the paired DNA-binding domain is required for assembly of Pax-Ets ternary complexes.

Authors:  W Wheat; D Fitzsimmons; H Lennox; S R Krautkramer; L N Gentile; L P McIntosh; J Hagman
Journal:  Mol Cell Biol       Date:  1999-03       Impact factor: 4.272

6.  2,3,7,8-tetrachlorodibenzo-p-dioxin induces transcriptional activity of the human polymorphic hs1,2 enhancer of the 3'Igh regulatory region.

Authors:  Tharu M Fernando; Sharon D Ochs; Jing Liu; Ruth C Chambers-Turner; Courtney E W Sulentic
Journal:  J Immunol       Date:  2012-02-22       Impact factor: 5.422

7.  A human non-XLA immunodeficiency disease characterized by blockage of B cell development at an early proB cell stage.

Authors:  E Meffre; F LeDeist; G de Saint-Basile; A Deville; M Fougereau; A Fischer; C Schiff
Journal:  J Clin Invest       Date:  1996-10-01       Impact factor: 14.808

8.  NK cells in the CD19- B220+ bone marrow fraction are increased in senescence and reduce E2A and surrogate light chain proteins in B cell precursors.

Authors:  Anne M King; Patricia Keating; Anjali Prabhu; Bonnie B Blomberg; Richard L Riley
Journal:  Mech Ageing Dev       Date:  2009-03-24       Impact factor: 5.432

9.  C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8.

Authors:  P Dörfler; M Busslinger
Journal:  EMBO J       Date:  1996-04-15       Impact factor: 11.598

10.  Noncoding RNA-guided recruitment of transcription factors: A prevalent but undocumented mechanism?

Authors:  Nara Lee; Joan A Steitz
Journal:  Bioessays       Date:  2015-07-22       Impact factor: 4.345
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.