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Literature DB >> 8662523

Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation.

Abstract

Proliferating murine C2C12 myoblasts can undergo either terminal differentiation or programmed cell death under conditions of mitogen deprivation. Unlike myoblasts, differentiated myotubes were resistant to apoptosis. During myogenesis the appearance of the apoptosis-resistant phenotype was correlated with the induction of the cyclin-dependent kinase (Cdk) inhibitor p21(CIP1) but not with the appearance of myogenin, a marker expressed earlier in differentiation. Forced expression of the Cdk inhibitors p21(CIP1) or p16(INK4A) blocked apoptosis during myocyte differentiation. These data indicate that induction of Cdk inhibitors may serve to protect differentiating myocytes from programmed cell death as well as play a role in establishing the postmitotic state.

Entities: Gene Species

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Year: 1996 PMID： 8662523 PMCID： PMC3641673 DOI： 10.1126/science.273.5273.359

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

25 in total

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Authors: F E STOCKDALE; H HOLTZER
Journal: Exp Cell Res Date: 1961-09 Impact factor: 3.905

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Journal: Cell Date: 1992-04-03 Impact factor: 41.582

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Journal: Mol Cell Biol Date: 1996-04 Impact factor: 4.272

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Journal: Genes Dev Date: 1993-07 Impact factor: 11.361

5. Commitment, fusion and biochemical differentiation of a myogenic cell line in the absence of DNA synthesis.

Authors: B Nadal-Ginard
Journal: Cell Date: 1978-11 Impact factor: 41.582

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Authors: M Serrano; E Gómez-Lahoz; R A DePinho; D Beach; D Bar-Sagi
Journal: Science Date: 1995-01-13 Impact factor: 47.728

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Journal: Cell Date: 1993-02-12 Impact factor: 41.582

8. Expression of the p16 and p15 cyclin-dependent kinase inhibitors in lymphocyte activation and neuronal differentiation.

Authors: A F Lois; L T Cooper; Y Geng; T Nobori; D Carson
Journal: Cancer Res Date: 1995-09-15 Impact factor: 12.701

9. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA.

Authors: J Chen; P K Jackson; M W Kirschner; A Dutta
Journal: Nature Date: 1995-03-23 Impact factor: 49.962

10. Inhibition of apoptosis by the retinoblastoma gene product.

Authors: D A Haas-Kogan; S C Kogan; D Levi; P Dazin; A T'Ang; Y K Fung; M A Israel
Journal: EMBO J Date: 1995-02-01 Impact factor: 11.598

98 in total

1. Cell cycle withdrawal promotes myogenic induction of Akt, a positive modulator of myocyte survival.

Authors: Y Fujio; K Guo; T Mano; Y Mitsuuchi; J R Testa; K Walsh
Journal: Mol Cell Biol Date: 1999-07 Impact factor: 4.272

2. Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27(Kip1).

Authors: K Hiromura; J W Pippin; M L Fero; J M Roberts; S J Shankland
Journal: J Clin Invest Date: 1999-03 Impact factor: 14.808

3. Insulin-like growth factor-mediated muscle cell survival: central roles for Akt and cyclin-dependent kinase inhibitor p21.

Authors: M A Lawlor; P Rotwein
Journal: Mol Cell Biol Date: 2000-12 Impact factor: 4.272

4. Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells.

Authors: D Chattopadhyay; M K Ghosh; A Mal; M L Harter
Journal: J Virol Date: 2001-10 Impact factor: 5.103

5. Carp, a cardiac ankyrin-repeated protein, and its new homologue, Arpp, are differentially expressed in heart, skeletal muscle, and rhabdomyosarcomas.

Authors: Naoko Ishiguro; Takeshi Baba; Tsuyoshi Ishida; Kengo Takeuchi; Mitsuhiko Osaki; Nobuhito Araki; Eikichi Okada; Satsuki Takahashi; Masahiro Saito; Mari Watanabe; Chisato Nakada; Yoshiyuki Tsukamoto; Kenzo Sato; Kinji Ito; Masashi Fukayama; Shigeo Mori; Hisao Ito; Masatsugu Moriyama
Journal: Am J Pathol Date: 2002-05 Impact factor: 4.307

6. Differentiation of human malignant melanoma cells that escape apoptosis after treatment with 9-nitrocamptothecin in vitro.

Authors: P Pantazis; D Chatterjee; Z Han; J Wyche
Journal: Neoplasia Date: 1999-08 Impact factor: 5.715