Literature DB >> 866194

CD studies on ribonuclease A - oligonucleotides interactions.

M D White, M Keren-Zur, Y Lapidot.   

Abstract

The interaction of ApU, Aps4U, Aps4Up, ApAps4Up and Gps4U with RNase A was studied by CD difference spectroscopy. The use of 4-thiouridine (s4U) containing oligonucleotides enables to distinguish between the interaction of the different components of the ligand with the enzyme. The mode of binding of the oligonucleotides to the enzyme is described. From this mode of binding it is explained why Aps4U, for example, inhibits RNase A, while s4UpA serves as a substrate.

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Year:  1977        PMID： 866194      PMCID： PMC342488          DOI： 10.1093/nar/4.4.843

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  12 in total

1.  Research on pancreatic ribonuclease. I. The inhibition of cyclic phospho-diesterase activity of bovine pancreatic ribonuclease by several substrate analogues.

Authors:  T UKITA; K WAKU; M IRIE; O HOSHINO
Journal:  J Biochem       Date:  1961-11       Impact factor: 3.387

2.  The preparation and properties of 4-thiouridine containing 2'-5' and 3'-5' dinucleoside monophosphates.

Authors:  M Keren-Zur; R Levy; Y Lapidot
Journal:  Nucleic Acids Res       Date:  1975-12       Impact factor: 16.971

3.  The properties of bovine pancreatic ribonuclease in ethylene glycol solution.

Authors:  H J SAGE; S J SINGER
Journal:  Biochemistry       Date:  1962-03       Impact factor: 3.162

4.  Correlation of the differences in conformation between 2'-5' and 3'-5' dinucleoside monophosphates with their behaviour on a sephadex LH-20 column.

Authors:  J L Sussman; I Barzilay; M Keren-Zur; Y Lapidot
Journal:  Biochim Biophys Acta       Date:  1973-05-10

5.  Conformational changes in some ribonuclease-inhibitor complexes.

Authors:  E R Simons
Journal:  Biochim Biophys Acta       Date:  1971-10

6.  Interaction of uridine-2'(3'),5'-diphosphate withibonuclease A and carboxymethylribonuclease A.

Authors:  F Sawada; M Irie
Journal:  J Biochem       Date:  1969-09       Impact factor: 3.387

7.  Optical rotatory dispersion and circular dichroism of sulfur-containing nucleosides and nucleotide and of the ribonuclease-thionucleotide complex.

Authors:  T Samejima; M Kita; M Saneyoshi; F Sawada
Journal:  Biochim Biophys Acta       Date:  1969-03-18

8.  On the binding of chitin oligosaccharides to lysozyme.

Authors:  F W Dahlquist; L Jao; M Raftery
Journal:  Proc Natl Acad Sci U S A       Date:  1966-07       Impact factor: 11.205

9.  Conformation of cytidine group in the complex of pancreatic ribonuclease A and cytidine-2'-phosphate.

Authors:  T Oshima; K Imahori
Journal:  J Biochem       Date:  1971-07       Impact factor: 3.387

10.  Magnesium-induced conformational change in transfer ribonucleic acid as measured by circular dichroism.

Authors:  G E Willick; C M Kay
Journal:  Biochemistry       Date:  1971-06-08       Impact factor: 3.162
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