T Yamada1, F Ohsugi, T Irie, C Ishii, S Sadaoka, S Tada. 1. Department of Radiology, The Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, Tokyo, 105 Japan.
Abstract
PURPOSE: Twenty-two patients with advanced gynecologic cancer underwent extended intraarterial cisplatin infusion after alteration of the intrapelvic blood flow and implantation of a vascular access device (VAD). METHODS: To maximize concentrations of cisplatin at the target lesion, the superior and inferior gluteal arteries were embolized with steel coils. The tip of the catheter was inserted into the internal iliac artery; the opposite end of the catheter was connected to the VAD. RESULTS: Intensive radioisotope accumulation was demonstrated in the anterior division of the pelvis, seen by scintigraphy performed with technetium 99m macroaggregated albumin via the VAD. Local perfusion in the tumor was well seen by ultrasonographic angiography with CO2 microbubbles via the VAD. Continuous consecutive infusion of cisplatin at a rate of 12.5 mg/day via the VAD minimized the toxicity. The overall response rate was 73%. Radical surgery was possible in 16 of the 22 patients after this intraarterial infusion. CONCLUSION: This method was useful for treating advanced gynecologic cancer without significant toxicity.
PURPOSE: Twenty-two patients with advanced gynecologic cancer underwent extended intraarterial cisplatin infusion after alteration of the intrapelvic blood flow and implantation of a vascular access device (VAD). METHODS: To maximize concentrations of cisplatin at the target lesion, the superior and inferior gluteal arteries were embolized with steel coils. The tip of the catheter was inserted into the internal iliac artery; the opposite end of the catheter was connected to the VAD. RESULTS: Intensive radioisotope accumulation was demonstrated in the anterior division of the pelvis, seen by scintigraphy performed with technetium 99m macroaggregated albumin via the VAD. Local perfusion in the tumor was well seen by ultrasonographic angiography with CO2 microbubbles via the VAD. Continuous consecutive infusion of cisplatin at a rate of 12.5 mg/day via the VAD minimized the toxicity. The overall response rate was 73%. Radical surgery was possible in 16 of the 22 patients after this intraarterial infusion. CONCLUSION: This method was useful for treating advanced gynecologic cancer without significant toxicity.
Authors: M R Posner; L Ferrari; J F Belliveau; F J Cummings; M C Wiemann; A O'Rourke; A B Weitberg; P Calabresi Journal: Cancer Date: 1987-01-01 Impact factor: 6.860
Authors: M A Rettenmaier; M F Moran; N F Ramsinghani; M Colman; N A Syed; A Puthawala; F W Jansen; P J DiSaia Journal: Cancer Date: 1988-04-01 Impact factor: 6.860
Authors: Y Yamashita; M Takahashi; H Bussaka; Y Korogi; R Saito; K Miyazaki; S Fujisaki; H Okamura Journal: Cardiovasc Intervent Radiol Date: 1989 Jul-Aug Impact factor: 2.740
Authors: D J Stewart; R S Benjamin; S Zimmerman; R M Caprioli; S Wallace; V Chuang; D Calvo; M Samuels; J Bonura; T L Loo Journal: Cancer Res Date: 1983-02 Impact factor: 12.701
Authors: J F Belliveau; M R Posner; L Ferrari; G W Crabtree; F J Cummings; M C Wiemann; G P O'Leary; H Griffin; M A Phaneuf; A O'Rourke Journal: Cancer Treat Rep Date: 1986-10
Authors: D B Calvo; Y Z Patt; S Wallace; V P Chuang; R S Benjamin; J D Pritchard; E M Hersh; G P Bodey; G M Mavligit Journal: Cancer Date: 1980-03-15 Impact factor: 6.860