Literature DB >> 8661023

YAC/STS map of 9 Mb of Xq26 at 100-kb resolution, localizing 6 ESTs, 6 genes, and 32 genetic markers.

G Pilia1, S MacMillan, R Nagaraja, S Mumm, J Weissenbach, D Schlessinger.   

Abstract

To facilitate functional analysis of the Xq26 region, the physical map has been extended across 9 Mb with 192 YACs and markers including 90 STSs (sequence-tagged sites) and 50 hybridization probes. Six genes and six ESTs are localized. In addition, 32 markers that detect polymorphism permit an integration of physical with genetic linkage data. The localizations of eight uncloned disease genes are thereby delimited on the physical map. The data also suggest a possible gradient of recombination across the cytogenetic band, with little or no recombination reported in the centromeric 3.5-4 Mb.

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Year:  1996        PMID： 8661023     DOI： 10.1006/geno.1996.0240

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  5 in total

1.  High-resolution landmark framework for the sequence-ready mapping of Xq23-q26.1.

Authors:  H E Steingruber; A Dunham; A J Coffey; S M Clegg; G R Howell; G L Maslen; C E Scott; R Gwilliam; P J Hunt; E C Sotheran; E J Huckle; S E Hunt; P Dhami; C Soderlund; M A Leversha; D R Bentley; M T Ross
Journal:  Genome Res       Date:  1999-08       Impact factor: 9.043

2.  Localisation of X linked recessive idiopathic hypoparathyroidism to a 1.5 Mb region on Xq26-q27.

Authors:  D Trump; P H Dixon; S Mumm; C Wooding; K E Davies; D Schlessinger; M P Whyte; R V Thakker
Journal:  J Med Genet       Date:  1998-11       Impact factor: 6.318

3.  Recovery and potential utility of YACs as circular YACs/BACs.

Authors:  M Cocchia; N Kouprina; S J Kim; V Larionov; D Schlessinger; R Nagaraja
Journal:  Nucleic Acids Res       Date:  2000-09-01       Impact factor: 16.971

4.  A submicroscopic deletion in Xq26 associated with familial situs ambiguus.

Authors:  G B Ferrero; M Gebbia; G Pilia; D Witte; A Peier; R J Hopkin; W J Craigen; L G Shaffer; D Schlessinger; A Ballabio; B Casey
Journal:  Am J Hum Genet       Date:  1997-08       Impact factor: 11.025

5.  Localisation of a gene for non-specific X linked mental retardation (MRX46) to Xq25-q26.

Authors:  H G Yntema; B C Hamel; A P Smits; T van Roosmalen; B van den Helm; H Kremer; H H Ropers; D F Smeets; H van Bokhoven
Journal:  J Med Genet       Date:  1998-10       Impact factor: 6.318
  5 in total

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