Literature DB >> 8660294

A cleavage-site-directed inhibitor of interleukin-1 beta-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes.

K Cain1, S H Inayat-Hussain, C Couet, G M Cohen.   

Abstract

Apoptosis induced in primary hepatocytes by transforming growth factor beta1 and staurosporine produced chromatin condensation, DNA cleavage is detected by in situ end-labelling, field inversion and conventional gel electrophoresis, and cell detachment. These effects were abolished by benzyloxycarbonyl-valinylalanylaspartylfluoromethyl ketone, a cleavage-site-directed inhibitor of interleukin-1beta-converting enzyme-like proteases, and this finding suggests that these enzymes are involved in liver apoptosis.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8660294      PMCID： PMC1217036          DOI： 10.1042/bj3140027

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  34 in total

1.  Fas-mediated apoptosis in primary cultured mouse hepatocytes.

Authors:  R Ni; Y Tomita; K Matsuda; A Ichihara; K Ishimura; J Ogasawara; S Nagata
Journal:  Exp Cell Res       Date:  1994-12       Impact factor: 3.905

2.  A pre-existing protease is a common effector of thymocyte apoptosis mediated by diverse stimuli.

Authors:  H O Fearnhead; A J Rivett; D Dinsdale; G M Cohen
Journal:  FEBS Lett       Date:  1995-01-09       Impact factor: 4.124

3.  Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress.

Authors:  D J McConkey; P Hartzell; P Nicotera; A H Wyllie; S Orrenius
Journal:  Toxicol Lett       Date:  1988-08       Impact factor: 4.372

4.  Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes.

Authors:  V M Weaver; B Lach; P R Walker; M Sikorska
Journal:  Biochem Cell Biol       Date:  1993 Sep-Oct       Impact factor: 3.626

5.  Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE.

Authors:  Y A Lazebnik; S H Kaufmann; S Desnoyers; G G Poirier; W C Earnshaw
Journal:  Nature       Date:  1994-09-22       Impact factor: 49.962

6.  DNA fragmentation into 200-250 and/or 30-50 kilobase pair fragments in rat liver nuclei is stimulated by Mg2+ alone and Ca2+/Mg2+ but not by Ca2+ alone.

Authors:  K Cain; S H Inayat-Hussain; J T Wolfe; G M Cohen
Journal:  FEBS Lett       Date:  1994-08-08       Impact factor: 4.124

7.  Effects of thiol agents on the accumulation of cadmium by rat liver parenchymal and Kupffer cells.

Authors:  D N Skilleter; K Cain
Journal:  Chem Biol Interact       Date:  1981-11       Impact factor: 5.192

Review 8.  TGF-beta-receptor-mediated signaling.

Authors:  R Derynck
Journal:  Trends Biochem Sci       Date:  1994-12       Impact factor: 13.807

9.  Inhibition of mature IL-1 beta production in murine macrophages and a murine model of inflammation by WIN 67694, an inhibitor of IL-1 beta converting enzyme.

Authors:  B E Miller; P A Krasney; D M Gauvin; K B Holbrook; D J Koonz; R V Abruzzese; R E Miller; K A Pagani; R E Dolle; M A Ator
Journal:  J Immunol       Date:  1995-02-01       Impact factor: 5.422

10.  CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

Authors:  T Fernandes-Alnemri; G Litwack; E S Alnemri
Journal:  J Biol Chem       Date:  1994-12-09       Impact factor: 5.157
View more
  16 in total

1.  Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.

Authors:  M D Jacobsen; M Weil; M C Raff
Journal:  J Cell Biol       Date:  1996-06       Impact factor: 10.539

2.  Effect of hepatocyte apoptosis induced by TNF-alpha on acute severe hepatitis in mouse models.

Authors:  Guo-Qing Zang; Xia-Qiu Zhou; Hong Yu; Qing Xie; Guo-Ming Zhao; Bin Wang; Qing Guo; Yue-Qin Xiang; Dan Liao
Journal:  World J Gastroenterol       Date:  2000-10       Impact factor: 5.742

3.  Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells.

Authors:  W C Hung; H C Chang; L Y Chuang
Journal:  Biochem J       Date:  1999-02-15       Impact factor: 3.857

4.  Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage.

Authors:  H Hara; R M Friedlander; V Gagliardini; C Ayata; K Fink; Z Huang; M Shimizu-Sasamata; J Yuan; M A Moskowitz
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-04       Impact factor: 11.205

5.  Activation of caspases and p53 by bovine herpesvirus 1 infection results in programmed cell death and efficient virus release.

Authors:  L R Devireddy; C J Jones
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

6.  Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32.

Authors:  E A Slee; H Zhu; S C Chow; M MacFarlane; D W Nicholson; G M Cohen
Journal:  Biochem J       Date:  1996-04-01       Impact factor: 3.857

7.  MDC1 cleavage by caspase-3: a novel mechanism for inactivating the DNA damage response during apoptosis.

Authors:  Stéphanie Solier; Yves Pommier
Journal:  Cancer Res       Date:  2010-12-08       Impact factor: 12.701

Review 8.  Caspases: the executioners of apoptosis.

Authors:  G M Cohen
Journal:  Biochem J       Date:  1997-08-15       Impact factor: 3.857

9.  Apoptosis and its suppression in hepatocytes culture.

Authors:  Nyaradzo T Mukwena; Mohamed Al-Rubeai
Journal:  Cytotechnology       Date:  2005-11-30       Impact factor: 2.058

10.  Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

Authors:  S A Susin; N Zamzami; M Castedo; T Hirsch; P Marchetti; A Macho; E Daugas; M Geuskens; G Kroemer
Journal:  J Exp Med       Date:  1996-10-01       Impact factor: 14.307
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.