Literature DB >> 8659526

mtDNA variation indicates Mongolia may have been the source for the founding population for the New World.

D A Merriwether1, W W Hall, A Vahlne, R E Ferrell.   

Abstract

mtDNA RFLP variation was analyzed in 42 Mongolians from Ulan Bator. All four founding lineage types (A [4.76%], B [2.38%], C [11.9%], and D [19.04%]) identified by Torroni and colleagues were detected. Seven of the nine founding lineage types proposed by Bailliet and colleagues and Merriwether and Ferrell were detected (A2 [4.76%], B [2.38%], C1 [11.9%], D1 [7.14%], D2 [11.9%], X6 [16.7%], and X7 [9.5%]). Sixty-four percent of these 42 individuals had "Amerindian founding lineage" haplotypes. A survey of 24 restriction sites yielded 16 polymorphic sites and 21 different haplotypes. The presence of all four of the founding lineages identified by the Torroni group (and seven of Merriwether and Ferrell's nine founding lineages), combined with Mongolia's location with respect to the Bering Strait, indicates that Mongolia is a potential location for the origin of the founders of the New World. Since lineage B, which is widely distributed in the New World, is absent in Siberia, we conclude that Mongolia or a geographic location common to both contemporary Mongolians and American aboriginals is the more likely origin of the founders of the New World.

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Year:  1996        PMID: 8659526      PMCID: PMC1915096     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN: 0002-9297            Impact factor:   11.025


  32 in total

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2.  Mitochondrial DNA polymorphism among five Asian populations.

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3.  Mitochondrial DNA polymorphism in Japanese. II. Analysis with restriction enzymes of four or five base pair recognition.

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Journal:  Hum Genet       Date:  1986-02       Impact factor: 4.132

4.  Intraspecific nucleotide sequence differences in the major noncoding region of human mitochondrial DNA.

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Journal:  Am J Hum Genet       Date:  1990-04       Impact factor: 11.025

5.  Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.

Authors:  R K Saiki; D H Gelfand; S Stoffel; S J Scharf; R Higuchi; G T Horn; K B Mullis; H A Erlich
Journal:  Science       Date:  1988-01-29       Impact factor: 47.728

6.  An Asian-specific 9-bp deletion of mitochondrial DNA is frequently found in Polynesians.

Authors:  M Hertzberg; K N Mickleson; S W Serjeantson; J F Prior; R J Trent
Journal:  Am J Hum Genet       Date:  1989-04       Impact factor: 11.025

7.  Mitochondrial DNA polymorphism in Japanese living in Hokkaido.

Authors:  S Harihara; M Hirai; K Omoto
Journal:  Jinrui Idengaku Zasshi       Date:  1986-06

8.  Mitochondrial DNA polymorphism in Japanese. I. Analysis with restriction enzymes of six base pair recognition.

Authors:  S Horai; T Gojobori; E Matsunaga
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

9.  Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages.

Authors:  T G Schurr; S W Ballinger; Y Y Gan; J A Hodge; D A Merriwether; D N Lawrence; W C Knowler; K M Weiss; D C Wallace
Journal:  Am J Hum Genet       Date:  1990-03       Impact factor: 11.025

10.  Geographic variation in human mitochondrial DNA from Papua New Guinea.

Authors:  M Stoneking; L B Jorde; K Bhatia; A C Wilson
Journal:  Genetics       Date:  1990-03       Impact factor: 4.562

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  30 in total

1.  mtDNA history of the Cayapa Amerinds of Ecuador: detection of additional founding lineages for the Native American populations.

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2.  mtDNA analysis of Nile River Valley populations: A genetic corridor or a barrier to migration?

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Review 3.  Freezer anthropology: new uses for old blood.

Authors:  D A Merriwether
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-01-29       Impact factor: 6.237

4.  The dual origin and Siberian affinities of Native American Y chromosomes.

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5.  The structure of diversity within New World mitochondrial DNA haplogroups: implications for the prehistory of North America.

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Journal:  Am J Hum Genet       Date:  2001-05-15       Impact factor: 11.025

7.  Mitochondrial genome diversity of Native Americans supports a single early entry of founder populations into America.

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8.  Y-chromosome evidence for differing ancient demographic histories in the Americas.

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Journal:  Am J Hum Genet       Date:  2003-07-28       Impact factor: 11.025

9.  Mitochondrial DNA and Y chromosome variation provides evidence for a recent common ancestry between Native Americans and Indigenous Altaians.

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Journal:  Am J Hum Genet       Date:  2012-01-25       Impact factor: 11.025

10.  Where the O2 goes to: preservation of human fetal oxygen delivery and consumption at high altitude.

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Journal:  J Physiol       Date:  2008-12-15       Impact factor: 5.182

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