Literature DB >> 8657753

Cytotoxicity and NMR spectral assignments of ergolide and bigelovin.

Q Wang1, B N Zhou, R W Zhang, Y Y Lin, L Z Lin, R R Gil, G A Cordell.   

Abstract

Two potent cytotoxic sesquiterpene lactones, ergolide (1) and bigelovin (2) were isolated from Inula hupehensis I. helianthus-aquatica and their structures and NMR data were assignment unambiguously by using a combination of one-and two-dimensional NMR techniques and computer modeling calculations.

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Year:  1996        PMID: 8657753     DOI: 10.1055/s-2006-957843

Source DB:  PubMed          Journal:  Planta Med        ISSN: 0032-0943            Impact factor:   3.352


  2 in total

1.  Ergolide, sesquiterpene lactone from Inula britannica, inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-kappaB.

Authors:  J Whan Han; B Gon Lee; Y Kee Kim; J Woo Yoon; H Kyoung Jin; S Hong; H Young Lee; K Ro Lee; H Woo Lee
Journal:  Br J Pharmacol       Date:  2001-06       Impact factor: 8.739

2.  Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells.

Authors:  Hao-hao Zhang; Shan Kuang; Ying Wang; Xiao-xiao Sun; Yuan Gu; Li-hong Hu; Qiang Yu
Journal:  Acta Pharmacol Sin       Date:  2015-01-26       Impact factor: 6.150

  2 in total

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