Literature DB >> 8657743

Antiplasmodial activities and cytotoxic effects of aqueous extracts and sesquiterpene lactones from Neurolaena lobata.

G François1, C M Passreiter, H J Woerdenbag, M Van Looveren.   

Abstract

Aqueous and lipophilic extracts of Neurolaena lobata (Asteraceae), obtained from Guatemala, were tested against Plasmodium falciparum in vitro. Moreover, sesquiterpene lactones, of the germacranolide and furanoheliangolide type, isolated from N. lobata, were shown to be active against P. falciparum in vitro. In addition to their antiplasmodial activity, their cytotoxic effects on human carcinoma cell lines were evaluated. Structure-activity relationships are discussed.

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Year:  1996        PMID： 8657743     DOI： 10.1055/s-2006-957833

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  11 in total

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2.  In vivo and in vitro antiplasmodial activities of some plants traditionally used in Guatemala against malaria.

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9.  Small compound 6-O-angeloylplenolin induces caspase-dependent apoptosis in human multiple myeloma cells.

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10.  Sesquiterpenes from Neurolaena lobata and their antiproliferative and anti-inflammatory activities.

Authors:  Ildikó Lajter; Andrea Vasas; Zoltán Béni; Peter Forgo; Markus Binder; Valery Bochkov; István Zupkó; Georg Krupitza; Richard Frisch; Brigitte Kopp; Judit Hohmann
Journal:  J Nat Prod       Date:  2014-01-29       Impact factor: 4.050
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