OBJECTIVE: To study whether the effect of cotreatment with human biosynthetic GH improves the outcome of poor IVF responders. DESIGN: A double-blind placebo-controlled study using a GnRH agonist (GnRH-a) and gonadotropin in a "boost" flare-up protocol for ovarian stimulation together with either placebo, 4, or 12 IU of human GH followed by oocyte retrieval and IVF-ET. PATIENTS: Twenty-two patients with previously demonstrated poor responses in at least two assisted reproductive technology cycles were recruited. INTERVENTIONS: Pretreatment and post-treatment blood samples and daily morning blood samples during ovarian stimulation were collected after an overnight fast. Human GH or placebo and GnRH-a were administered SC; gonadotropin was administered IM. Oocytes were collected by ultrasound-guided transvaginal aspiration of follicles. Embryos were cultured in vitro and transferred transcervically. MAIN OUTCOME MEASURES: Serum E2, FSH, GH, insulin-like growth factor-I (IGF-1), IGF binding protein 1 (IGFBP-1), and IGFBP-3 concentrations. Number of FSH ampules, follicles, oocytes, embryos, and pregnancies. RESULTS: No improvement in cycle outcome was demonstrated with daily adjuvant human GH administration with either 4 or 12 IU. Serum IGF-I levels were highest in the 12 IU human GH group and lowest in the placebo group. Serum IGFBP-3 levels increased 2 days after IGF-I levels in the 12 IU human GH group only. Serum IGFBP-1 levels were unchanged in all groups. CONCLUSION: Poor IVF responders do not benefit from cotreatment with human GH during their ovarian stimulation.
RCT Entities:
OBJECTIVE: To study whether the effect of cotreatment with human biosynthetic GH improves the outcome of poor IVF responders. DESIGN: A double-blind placebo-controlled study using a GnRH agonist (GnRH-a) and gonadotropin in a "boost" flare-up protocol for ovarian stimulation together with either placebo, 4, or 12 IU of human GH followed by oocyte retrieval and IVF-ET. PATIENTS: Twenty-two patients with previously demonstrated poor responses in at least two assisted reproductive technology cycles were recruited. INTERVENTIONS: Pretreatment and post-treatment blood samples and daily morning blood samples during ovarian stimulation were collected after an overnight fast. Human GH or placebo and GnRH-a were administered SC; gonadotropin was administered IM. Oocytes were collected by ultrasound-guided transvaginal aspiration of follicles. Embryos were cultured in vitro and transferred transcervically. MAIN OUTCOME MEASURES: Serum E2, FSH, GH, insulin-like growth factor-I (IGF-1), IGF binding protein 1 (IGFBP-1), and IGFBP-3 concentrations. Number of FSH ampules, follicles, oocytes, embryos, and pregnancies. RESULTS: No improvement in cycle outcome was demonstrated with daily adjuvant human GH administration with either 4 or 12 IU. Serum IGF-I levels were highest in the 12 IU human GH group and lowest in the placebo group. Serum IGFBP-3 levels increased 2 days after IGF-I levels in the 12 IU human GH group only. Serum IGFBP-1 levels were unchanged in all groups. CONCLUSION: Poor IVF responders do not benefit from cotreatment with human GH during their ovarian stimulation.
Authors: Menilson Menezes; Roberto Salvatori; Carla R P Oliveira; Rossana M C Pereira; Anita H O Souza; Luciana M A Nobrega; Edla A C Cruz; Marcos Menezes; Erica O Alves; Manuel H Aguiar-Oliveira Journal: Menopause Date: 2008 Jul-Aug Impact factor: 2.953
Authors: Carlo Alviggi; Peter Humaidan; Colin M Howles; Donald Tredway; Stephen G Hillier Journal: Reprod Biol Endocrinol Date: 2009-09-22 Impact factor: 5.211
Authors: Kevin N Keane; Peter M Hinchliffe; Philip K Rowlands; Gayatri Borude; Shanti Srinivasan; Satvinder S Dhaliwal; John L Yovich Journal: Front Endocrinol (Lausanne) Date: 2018-01-31 Impact factor: 5.555