Literature DB >> 8653416

Effects of a vigilance-enhancing drug, modafinil, on rat brain metabolism: a 2D COSY 1H-NMR study.

C Piérard1, P Satabin, D Lagarde, B Barrère, C Y Guezennec, J P Menu, M Pérès.   

Abstract

The effects of modafinil, a vigilance-enhancing drug, on brain metabolism were investigated directly in situ by the 2D COSY 1H-NMR spectroscopy in anesthetized rats. Modafinil (600 mg/kg, i.p.) induced significant increases in both aspartate (72% +/- 15%) and glutamate-glutamine pool (28% +/- 8%) simultaneously with increases in inositol (51% +/- 19%) and creatine-phosphocreatine pool (47% +/- 14%) in comparison with control values (P < 0.05; n = 5). These results suggest that the awakening properties of modafinil could be mediated by metabolic activation.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 8653416     DOI： 10.1016/0006-8993(95)00711-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  10 in total

1.  Stress modulation of the memory retrograde-enhancing effects of the awakening drug modafinil in mice.

Authors:  Daniel Béracochéa; Pierrette Liscia; Christophe Tronche; Frédéric Chauveau; Jean-Claude Jouanin; Christophe Piérard
Journal:  Psychopharmacology (Berl)       Date:  2007-10-13       Impact factor: 4.530

Review 2.  In vivo 2D magnetic resonance spectroscopy of small animals.

Authors:  P Méric; G Autret; B T Doan; B Gillet; C Sébrié; J-C Beloeil
Journal:  MAGMA       Date:  2004-12-29       Impact factor: 2.310

3.  Modafinil : A Review of its Pharmacology and Clinical Efficacy in the Management of Narcolepsy.

Authors:  K J McClellan; C M Spencer
Journal:  CNS Drugs       Date:  1998-04       Impact factor: 5.749

Review 4.  Pharmacogenetic tools for the development of target-oriented cognitive-enhancing drugs.

Authors:  José A Apud; Daniel R Weinberger
Journal:  NeuroRx       Date:  2006-01

Review 5.  The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders.

Authors:  Maddalena Mereu; Antonello Bonci; Amy Hauck Newman; Gianluigi Tanda
Journal:  Psychopharmacology (Berl)       Date:  2013-08-10       Impact factor: 4.530

6.  Neuropharmacological and neurobiological relevance of in vivo ¹H-MRS of GABA and glutamate for preclinical drug discovery in mental disorders.

Authors:  Conny F Waschkies; Andreas Bruns; Stephan Müller; Martin Kapps; Edilio Borroni; Markus von Kienlin; Markus Rudin; Basil Künnecke
Journal:  Neuropsychopharmacology       Date:  2014-04-03       Impact factor: 7.853

7.  Localized 2D correlation spectroscopy in human brain at 3 T.

Authors:  Anne Ziegler; Brigitte Gillet; Jean-Claude Beloeil; Jean-Paul Macher; Michel Décorps; Jean-François Nédelec
Journal:  MAGMA       Date:  2002-03       Impact factor: 2.533

8.  High resolution mapping of modafinil induced changes in glutamate level in rat brain.

Authors:  Mohammad Haris; Anup Singh; Kejia Cai; Kavindra Nath; Gaurav Verma; Ravi Prakash Reddy Nanga; Hari Hariharan; John A Detre; Neill Epperson; Ravinder Reddy
Journal:  PLoS One       Date:  2014-07-28       Impact factor: 3.240

9.  MIDAS (Modafinil in Debilitating Fatigue After Stroke): A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial.

Authors:  Andrew Bivard; Thomas Lillicrap; Venkatesh Krishnamurthy; Elizabeth Holliday; John Attia; Heather Pagram; Michael Nilsson; Mark Parsons; Christopher R Levi
Journal:  Stroke       Date:  2017-04-12       Impact factor: 7.914

10.  Mechanisms of modafinil: A review of current research.

Authors:  Paul Gerrard; Robert Malcolm
Journal:  Neuropsychiatr Dis Treat       Date:  2007-06       Impact factor: 2.570
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.