K M Feldkircher1, A M Mistry, D R Romsos. 1. Department of Food Science and Human Nutrition, Michigan State University, East Lansing, 48824-1224, USA.
Abstract
OBJECTIVE: To determine if adrenalectomy would reverse the pre-existing gross obesity, characteristic of adult genetically obese (ob/ob) mice. DESIGN: Adult (12 week old) female ob/ob mice were adrenalectomized and fed a stock diet for 6 or 14 weeks. They were housed at 23-25 degrees C or 33 degrees C. Food intake and total body energy were determined. RESULTS: Adrenalectomy abolished the hyperphagia characteristic of ob/ob mice. Adrenalectomized ob/ob mice consumed 8-17% less food than intact lean mice. Adrenalectomized ob/ob mice housed at 23-25 degrees C lost 55% of their pre-existing body energy within 6 weeks after surgery and 75% of their body energy within 14 weeks after surgery. At 14 weeks after surgery, body weights and body energy content of the adrenalectomized ob/ob mice were comparable with values for intact lean mice. Intact ob/ob mice pair-fed to adrenalectomized ob/ob mice lost only half as much body energy as the adrenalectomized ob/ob mice did, indicating that adrenalectomy not only diminished food intake in ob/ob mice but also increased their energy expenditure per unit food consumed. Adrenalectomized ob/ob mice housed at 33 degrees C lost only half as much body energy in 6 weeks as did mice housed at 23-25 degrees C. CONCLUSION: Adrenalectomy reverses the gross obesity characteristic of adult ob/ob mice by abolishing their hyperphagia and increasing their energy expenditure per unit food consumed.
OBJECTIVE: To determine if adrenalectomy would reverse the pre-existing gross obesity, characteristic of adult genetically obese (ob/ob) mice. DESIGN: Adult (12 week old) female ob/ob mice were adrenalectomized and fed a stock diet for 6 or 14 weeks. They were housed at 23-25 degrees C or 33 degrees C. Food intake and total body energy were determined. RESULTS: Adrenalectomy abolished the hyperphagia characteristic of ob/ob mice. Adrenalectomized ob/ob mice consumed 8-17% less food than intact lean mice. Adrenalectomized ob/ob mice housed at 23-25 degrees C lost 55% of their pre-existing body energy within 6 weeks after surgery and 75% of their body energy within 14 weeks after surgery. At 14 weeks after surgery, body weights and body energy content of the adrenalectomized ob/ob mice were comparable with values for intact lean mice. Intact ob/ob mice pair-fed to adrenalectomized ob/ob mice lost only half as much body energy as the adrenalectomized ob/ob mice did, indicating that adrenalectomy not only diminished food intake in ob/ob mice but also increased their energy expenditure per unit food consumed. Adrenalectomized ob/ob mice housed at 33 degrees C lost only half as much body energy in 6 weeks as did mice housed at 23-25 degrees C. CONCLUSION: Adrenalectomy reverses the gross obesity characteristic of adult ob/ob mice by abolishing their hyperphagia and increasing their energy expenditure per unit food consumed.
Authors: Michael M Mendelson; Riccardo E Marioni; Roby Joehanes; Chunyu Liu; Åsa K Hedman; Stella Aslibekyan; Ellen W Demerath; Weihua Guan; Degui Zhi; Chen Yao; Tianxiao Huan; Christine Willinger; Brian Chen; Paul Courchesne; Michael Multhaup; Marguerite R Irvin; Ariella Cohain; Eric E Schadt; Megan L Grove; Jan Bressler; Kari North; Johan Sundström; Stefan Gustafsson; Sonia Shah; Allan F McRae; Sarah E Harris; Jude Gibson; Paul Redmond; Janie Corley; Lee Murphy; John M Starr; Erica Kleinbrink; Leonard Lipovich; Peter M Visscher; Naomi R Wray; Ronald M Krauss; Daniele Fallin; Andrew Feinberg; Devin M Absher; Myriam Fornage; James S Pankow; Lars Lind; Caroline Fox; Erik Ingelsson; Donna K Arnett; Eric Boerwinkle; Liming Liang; Daniel Levy; Ian J Deary Journal: PLoS Med Date: 2017-01-17 Impact factor: 11.069
Authors: Rachel J Perry; Jon M Resch; Amelia M Douglass; Joseph C Madara; Aviva Rabin-Court; Hakan Kucukdereli; Chen Wu; Joongyu D Song; Bradford B Lowell; Gerald I Shulman Journal: Proc Natl Acad Sci U S A Date: 2019-06-18 Impact factor: 11.205