BACKGROUND AND DESIGN: Ultrasound imaging, while initially developed to visualize internal organs, is now being applied to image the skin. In this preliminary study, we used a high-frequency, 40-MHz ultrasound imaging system to provide high-resolution images in psoriasis and examined the relationship between clinical and ultrasound ratings in plaque-type psoriasis. The ultrasound image of a psoriatic plaque demonstrates a superficial echogenic band (band A), followed by a nonchogenic band (band B), and a deeper echogenic band (band C). RESULTS: In psoriatic plaques (N = 145), the severity of the psoriasis as assessed according to the degree of scaling, erythema, and thickness (SET score) correlated best with the width of band B (P < .001, r = 0.86) and less well with the width of bands A (P < .001, r = 0.59) and C (P < .001, r = 0.44). For the treated psoriatic plaques (n = 64), for which paired readings were available before and after therapy, changes in the SET scores correlated best with the change in the width of band B (P < .001, r = 0.96) and less well with the change in the width of bands A (P < .001, r = 0.61) and C (P < .001, r = 0.45). Ultrasound analyses and clinical evaluation were performed by independent raters. CONCLUSIONS: The data suggest that high-frequency ultrasound imaging may prove to be a noninvasive technique that can be used as an adjunct to the clinical evaluation of the lesional severity of psoriatic plaques.
BACKGROUND AND DESIGN: Ultrasound imaging, while initially developed to visualize internal organs, is now being applied to image the skin. In this preliminary study, we used a high-frequency, 40-MHz ultrasound imaging system to provide high-resolution images in psoriasis and examined the relationship between clinical and ultrasound ratings in plaque-type psoriasis. The ultrasound image of a psoriatic plaque demonstrates a superficial echogenic band (band A), followed by a nonchogenic band (band B), and a deeper echogenic band (band C). RESULTS: In psoriatic plaques (N = 145), the severity of the psoriasis as assessed according to the degree of scaling, erythema, and thickness (SET score) correlated best with the width of band B (P < .001, r = 0.86) and less well with the width of bands A (P < .001, r = 0.59) and C (P < .001, r = 0.44). For the treated psoriatic plaques (n = 64), for which paired readings were available before and after therapy, changes in the SET scores correlated best with the change in the width of band B (P < .001, r = 0.96) and less well with the change in the width of bands A (P < .001, r = 0.61) and C (P < .001, r = 0.45). Ultrasound analyses and clinical evaluation were performed by independent raters. CONCLUSIONS: The data suggest that high-frequency ultrasound imaging may prove to be a noninvasive technique that can be used as an adjunct to the clinical evaluation of the lesional severity of psoriatic plaques.
Authors: Mihaela Cristina Șomlea; Andreea Nicoleta Boca; Alexandra Dana Pop; Roxana Flavia Ilieș; Stefan Cristian Vesa; Anca Dana Buzoianu; Alexandru Tătaru Journal: Exp Ther Med Date: 2019-10-29 Impact factor: 2.447
Authors: G Berstein; Y Zhang; Z Berger; E Kieras; G Li; A Samuel; T Yeoh; H Dowty; K Beaumont; W Wigger-Alberti; Y von Mackensen; U Kroencke; R Hamscho; S Garcet; J G Krueger; C Banfield; B Oemar Journal: Clin Exp Dermatol Date: 2020-09-14 Impact factor: 3.470