Literature DB >> 8650261

Interleukin 1 (IL1) and tumour necrosis factor (TNF) signal transduction.

J Saklatvala1, W Davis, F Guesdon.   

Abstract

The inflammatory cytokines interleukin 1 (IL1) and tumour necrosis factor (TNF) have a broad range of physiological effects. Whereas their immediate post-receptor events are not well understood, both have the potential to activate a range of protein kinases. These include the three types of mitogen activated protein (MAP) kinase (ERK, JNK/p54 and p38) and a beta-casein kinase. The mechanisms by which these kinases are activated is discussed and the significance of their activation for particular biological responses is assessed.

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Year:  1996        PMID： 8650261     DOI： 10.1098/rstb.1996.0011

Source DB:  PubMed          Journal:  Philos Trans R Soc Lond B Biol Sci        ISSN： 0962-8436            Impact factor:   6.237


  23 in total

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