Literature DB >> 8649585

Epsilon 4 allele of apolipoprotein E increases risk of Alzheimer's disease in a Chinese population.

C J Hong1, T Y Liu, H C Liu, S J Wang, J L Fuh, C W Chi, K Y Lee, C B Sim.   

Abstract

We examined the apolipoprotein E genotype in 56 Chinese patients with late-onset sporadic Alzheimer's disease (AD) and 57 Chinese control subjects of similar age. The frequency of epsilon 4 in the AD group was significantly higher than that in the control group (23.2% versus 7.9%, p = 0.003). The odds ratio for AD in individuals with either one or two epsilon 4 was 2.96 (95% CI 1.11 to 8.03). The linear trend for AD in proportion to alleles of epsilon 4 was also significant (chi 2 = 8.2, p = 0.004). Our results support the association between epsilon 4 and AD in the Chinese.

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Year:  1996        PMID： 8649585     DOI： 10.1212/wnl.46.6.1749

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


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