| Literature DB >> 8648226 |
S Sei1, H Akiyoshi, J Bernard, D J Venzon, C H Fox, D J Schwartzentruber, B D Anderson, J B Kopp, B U Mueller, P A Pizzo.
Abstract
To investigate the dynamic interplay between human immunodeficiency virus type I (HIV-1) replication and the extent of immune destruction in HIV-1-infected children, virus burden in lymphoid tissues (LN) and peripheral blood was compared with changes in LN architecture and cytokine levels constitutively expressed in LN. In agreement with results of a preliminary study, the plasma HIV-1 RNA level correlated with the amount of provirus in LN. However, the level was also associated with a degree of destruction of lymphoid follicular architecture and an alteration of immune cytokine expression. Expression of interleukin (IL)-4 was higher in LN with higher virus replication. Reduction of plasma viremia was associated with an increase in IL-2 mRNA levels in LN. These findings suggest that measurable virus burden in the peripheral blood is not a simple reflection of viral replication in LN but is also influenced by the extent of progressive immune destruction.Entities:
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Year: 1996 PMID： 8648226 DOI： 10.1093/infdis/173.6.1485
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226