| Literature DB >> 8648203 |
G D Hussey1, E A Goddard, J Hughes, J J Ryon, M Kerran, E Carelse, P M Strebel, L E Markowitz, J Moodie, P Barron, Z Latief, R Sayed, D Beatty, D E Griffin.
Abstract
The effects of measles immunization on immune responses in infants and the roles of vaccine strain and age of immunization are not known. Eighty-eight children were immunized at 6 or 9 months of age with the Edmonston-Zagreb (EZ) or Schwarz (SW6, SW9) strain of measles vaccine. Children were studied before and 2 weeks and 3 months after immunization. Seroconversion was similar, but geometric mean neutralizing titers at 3 months differed by vaccine group: SW9, 1367 mIU/mL; SW6, 982; and EZ, 303 (P = .003). Mitogen-induced lymphoproliferation was decreased at 2 weeks in the SW9 group and at 3 months in all groups and was negatively correlated with measles antibody level at 3 months (r = -.387, P = .003). CD8 T cells, soluble CD8, neopterin, and beta2-microglobulin were increased at 2 weeks in the SW9 group, and soluble CD8 and beta2-microglobulin remained elevated at 3 months. Therefore, measles immunization resulted in suppression of lymphoproliferation, which was most evident in infants with the highest antibody responses and most immune activation.Entities:
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Year: 1996 PMID： 8648203 DOI： 10.1093/infdis/173.6.1320
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226