BACKGROUND: Prognostic indicators that could assist in a more precise selection of patients with oral cancer for differentiated therapy would be clinically valuable. METHODS: A consecutive series of 161 cases of intraoral squamous cell carcinoma (SCC) occurring during a 5-year period in a population of 1.4 million inhabitants, was evaluated by histopathologic (the modified classification of Jakobsson et al.), stereologic, clinical, and epidemiologic parameters and the serum markers hemoglobin and rhesus blood group. RESULTS: Univariate analysis established a significant prognostic value in terms of cause-specific survival for T stage (P < .0001), stage (P < .0001), maximum tumor diameter (P < .0001), N stage (N+/NO) (P < .0001), alcohol consumption (P = .03), stereologic estimates of nuclear volume (P = .04), and the histomorphologic parameters mode of invasion (P = .001), pattern (P = .01), vascular invasion (P = .02), depth (P = .006), and mean histologic score. Tobacco consumption was borderline significant (P = .055). A multivariate analysis using the Cox proportional hazard analysis showed that both clinical (stage, P < .0001; size, P = .0027), epidemiologic (tobacco consumption, P = .0054), morphohistopathologic (mode of invasion P < .0001), and stereologic (nuclear volume, P = .0010) parameters had an independent significant effect on survival. Inversely, the mean histologic score had no prognostic value. From the final regression model prognostic forecasts were calculated. Twelve patients (25%) with stage I disease had unfavorable histologic and stereologic parameters. The observed survival (+/- 1 standard error of the estimate) for these patients was 33% +/- 18%. The observed survival for stage I patients with more favorable histologic and stereologic characteristics (n = 36) was 76% +/- 8%. CONCLUSION: The use of a combination of clinical, histologic, epidemiologic, and stereologic parameters will assist the design of treatment strategies for intraoral SCC.
BACKGROUND: Prognostic indicators that could assist in a more precise selection of patients with oral cancer for differentiated therapy would be clinically valuable. METHODS: A consecutive series of 161 cases of intraoral squamous cell carcinoma (SCC) occurring during a 5-year period in a population of 1.4 million inhabitants, was evaluated by histopathologic (the modified classification of Jakobsson et al.), stereologic, clinical, and epidemiologic parameters and the serum markers hemoglobin and rhesus blood group. RESULTS: Univariate analysis established a significant prognostic value in terms of cause-specific survival for T stage (P < .0001), stage (P < .0001), maximum tumor diameter (P < .0001), N stage (N+/NO) (P < .0001), alcohol consumption (P = .03), stereologic estimates of nuclear volume (P = .04), and the histomorphologic parameters mode of invasion (P = .001), pattern (P = .01), vascular invasion (P = .02), depth (P = .006), and mean histologic score. Tobacco consumption was borderline significant (P = .055). A multivariate analysis using the Cox proportional hazard analysis showed that both clinical (stage, P < .0001; size, P = .0027), epidemiologic (tobacco consumption, P = .0054), morphohistopathologic (mode of invasion P < .0001), and stereologic (nuclear volume, P = .0010) parameters had an independent significant effect on survival. Inversely, the mean histologic score had no prognostic value. From the final regression model prognostic forecasts were calculated. Twelve patients (25%) with stage I disease had unfavorable histologic and stereologic parameters. The observed survival (+/- 1 standard error of the estimate) for these patients was 33% +/- 18%. The observed survival for stage I patients with more favorable histologic and stereologic characteristics (n = 36) was 76% +/- 8%. CONCLUSION: The use of a combination of clinical, histologic, epidemiologic, and stereologic parameters will assist the design of treatment strategies for intraoral SCC.
Authors: Terry A Day; Betsy K Davis; M Boyd Gillespie; John K Joe; Megan Kibbey; Bonnie Martin-Harris; Brad Neville; Mary S Richardson; Steven Rosenzweig; Anand K Sharma; Michelle M Smith; Stacy Stewart; Robert K Stuart Journal: Curr Treat Options Oncol Date: 2003-02
Authors: Ayan Tyagi Kumar; Alexander Knops; Brian Swendseid; Ubaldo Martinez-Outschoom; Larry Harshyne; Nancy Philp; Ulrich Rodeck; Adam Luginbuhl; David Cognetti; Jennifer Johnson; Joseph Curry Journal: Front Oncol Date: 2019-07-23 Impact factor: 6.244
Authors: Angela Santoro; Giuseppe Pannone; Silvana Papagerakis; H Stan McGuff; Barbara Cafarelli; Silvia Lepore; Salvatore De Maria; Corrado Rubini; Marilena Mattoni; Stefania Staibano; Ernesto Mezza; Gaetano De Rosa; Gabriella Aquino; Simona Losito; Carla Loreto; Salvatore Crimi; Pantaleo Bufo; Lorenzo Lo Muzio Journal: Biomed Res Int Date: 2014-01-08 Impact factor: 3.411
Authors: P Cariati; A Cabello-Serrano; M Perez-de Perceval-Tara; F Monsalve-Iglesias; I Martínez-Lara Journal: Med Oral Patol Oral Cir Bucal Date: 2017-11-01