Literature DB >> 8647655

Oxytocin and oxytocin-analogue F314 inhibit cell proliferation and tumor growth of rat and mouse mammary carcinomas.

P Cassoni1, A Sapino, M Papotti, G Bussolati.   

Abstract

The effects of oxytocin (OT) and the OT-analogue F314 were investigated an xenografts of mouse mammary and colon carcinomas (TS/A and C26 tumors) and of rat mammary carcinoma (D-R3230AC). In all cases, proliferation was previously assessed by cell counting in cultured cell lines, whereas tumor growth was checked by serial measures of tumor volume and by evaluation of tumor weight at the end of the experiment. Both cell proliferation and tumor growth were inhibited by OT and F314. These data support previous observations on the inhibitory effect of OT and F314 on the growth of MCF7, T47D and MDA-MB231 human breast cancer cell lines and open new prospects for testing the effect of this hypothalamic hormone and its analogues on the control of breast carcinoma growth.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8647655     DOI： 10.1002/(SICI)1097-0215(19960611)66:6<817::AID-IJC18>3.0.CO;2-#

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  14 in total

1.  Functional selective oxytocin-derived agonists discriminate between individual G protein family subtypes.

Authors:  Marta Busnelli; Aude Saulière; Maurice Manning; Michel Bouvier; Celine Galés; Bice Chini
Journal:  J Biol Chem       Date:  2011-11-08       Impact factor: 5.157

2.  Oxytocin stimulates secretory processes in lactating rabbit mammary epithelial cells.

Authors:  Vanessa Lollivier; Pierre-Guy Marnet; Serge Delpal; Dominique Rainteau; Caroline Achard; Aline Rabot; Michèle Ollivier-Bousquet
Journal:  J Physiol       Date:  2005-09-15       Impact factor: 5.182

3.  Estradiol and progesterone regulate oxytocin receptor binding and expression in human breast cancer cell lines.

Authors:  Janet A Amico; Phillip N Rauk; Hou-ming Cai
Journal:  Endocrine       Date:  2002-06       Impact factor: 3.633

Review 4.  Differentiation and cancer in the mammary gland: shedding light on an old dichotomy.

Authors:  O W Petersen; L Rønnov-Jessen; V M Weaver; M J Bissell
Journal:  Adv Cancer Res       Date:  1998       Impact factor: 6.242

Review 5.  REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy.

Authors:  Cedric Viero; Izumi Shibuya; Naoki Kitamura; Alexei Verkhratsky; Hiroaki Fujihara; Akiko Katoh; Yoichi Ueta; Hans H Zingg; Alexandr Chvatal; Eva Sykova; Govindan Dayanithi
Journal:  CNS Neurosci Ther       Date:  2010-07-07       Impact factor: 5.243

Review 6.  Oxytocin in the Male Reproductive Tract; The Therapeutic Potential of Oxytocin-Agonists and-Antagonists.

Authors:  Beatrix Stadler; Michael R Whittaker; Betty Exintaris; Ralf Middendorff
Journal:  Front Endocrinol (Lausanne)       Date:  2020-10-22       Impact factor: 5.555

Review 7.  Oxytocin receptor signaling in myoepithelial and cancer cells.

Authors:  Alessandra Reversi; Paola Cassoni; Bice Chini
Journal:  J Mammary Gland Biol Neoplasia       Date:  2005-07       Impact factor: 2.698

8.  Antiproliferative Effects of Oxytocin and Desmopressin on Canine Mammary Cancer Cells.

Authors:  Micaela Andrea Benavente; Carolina Paula Bianchi; Fernanda Imperiale; Marcelo Alfredo Aba
Journal:  Front Vet Sci       Date:  2016-12-26

9.  The roles of oxytocin and CD38 in social or parental behaviors.

Authors:  Olga Lopatina; Alena Inzhutova; Alla B Salmina; Haruhiro Higashida
Journal:  Front Neurosci       Date:  2013-01-11       Impact factor: 4.677

Review 10.  Oxytocin and cancer: An emerging link.

Authors:  Ben Lerman; Trisheena Harricharran; Olorunseun O Ogunwobi
Journal:  World J Clin Oncol       Date:  2018-09-14
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.