Literature DB >> 8647467

Characterization of the gene encoding murine heparin-binding epidermal growth factor-like growth factor.

P A Harding1, D R Brigstock, L Shen, M A Crissman-Combs, G E Besner.   

Abstract

The mouse gene (mHB-EGF) encoding heparin-binding epidermal growth factor-like growth factor was isolated from a mouse 129SVJ genomic library. DNA sequence analysis confirmed that the clone contained six exons (I-VI) and five introns (A-E), and spanned approx. 14 kb of DNA. PCR analysis showed that introns A-E of mHB-EGF are 203 bp, 2.5 kb, 5.5 kb, 825 bp and 272 bp in length, respectively. These results establish that mHB-EGF is similar in organization to human HB-EGF (hHB-EGF). However, DNA sequence analysis of introns A-E of mHB-EGF failed to show significant overall homology with those of hHB-EGF.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8647467     DOI： 10.1016/0378-1119(95)00861-6

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  3 in total

1.  Heparin-binding EGF-like growth factor is up-regulated in the obstructed kidney in a cell- and region-specific manner and acts to inhibit apoptosis.

Authors:  H T Nguyen; S H Bride; A B Badawy; R M Adam; J Lin; A Orsola; P D Guthrie; M R Freeman; C A Peters
Journal:  Am J Pathol       Date:  2000-03       Impact factor: 4.307

Review 2.  Heparin-Binding Epidermal Growth Factor-Like Growth Factor as a Critical Mediator of Tissue Repair and Regeneration.

Authors:  Duy T Dao; Lorenzo Anez-Bustillos; Rosalyn M Adam; Mark Puder; Diane R Bielenberg
Journal:  Am J Pathol       Date:  2018-08-22       Impact factor: 4.307

3.  Amino-terminal deletion of heparin-binding epidermal growth factor-like growth factor4-127 stimulates cell proliferation but lacks insulin-like activity.

Authors:  Z Zhou; P A Harding
Journal:  Cell Prolif       Date:  2007-04       Impact factor: 6.831
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.