PURPOSE: To define the value of contrast-enhanced MR mammography in ductal carcinoma in situ (DCIS). MATERIAL AND METHODS: In a group of 35 patients with DCIS, the results of MR imaging were compared to histopathology and immunohistochemistry in a retrospective study. RESULTS: In 35 patients with DCIS, a signal enhancement was found in 25 cases (72%). In 15 of these cases, the signal time curve was typical for malignancy. The other 10 patients had non-specific signal curves. Six of 35 patients (11%) had no enhancement within the tumour region. Four of 35 patients (11%) had bilateral diffuse signal increase, and regions of DCIS could not be identified clearly. Three DCIS were visualised exclusively by MR mammography. The configuration of signal enhancement was sharp (32%), unsharp (48%) or dendritic (20%). DCIS of the comedo type showed a significantly higher enhancement than the non-comedo type. A significant correlation between the grade of vascularisation in immunohistochemistry and signal enhancement in MR mammography could not be demonstrated. CONCLUSION: Dynamic MR mammography does not reliably visualise DCIS.
PURPOSE: To define the value of contrast-enhanced MR mammography in ductal carcinoma in situ (DCIS). MATERIAL AND METHODS: In a group of 35 patients with DCIS, the results of MR imaging were compared to histopathology and immunohistochemistry in a retrospective study. RESULTS: In 35 patients with DCIS, a signal enhancement was found in 25 cases (72%). In 15 of these cases, the signal time curve was typical for malignancy. The other 10 patients had non-specific signal curves. Six of 35 patients (11%) had no enhancement within the tumour region. Four of 35 patients (11%) had bilateral diffuse signal increase, and regions of DCIS could not be identified clearly. Three DCIS were visualised exclusively by MR mammography. The configuration of signal enhancement was sharp (32%), unsharp (48%) or dendritic (20%). DCIS of the comedo type showed a significantly higher enhancement than the non-comedo type. A significant correlation between the grade of vascularisation in immunohistochemistry and signal enhancement in MR mammography could not be demonstrated. CONCLUSION: Dynamic MR mammography does not reliably visualise DCIS.
Authors: Gerda Leinsinger; Thomas Schlossbauer; Michael Scherr; Oliver Lange; Maximilian Reiser; Axel Wismüller Journal: Eur Radiol Date: 2006-01-18 Impact factor: 5.315
Authors: F Sardanelli; L Bacigalupo; L Carbonaro; A Esseridou; G M Giuseppetti; P Panizza; V Lattanzio; A Del Maschio Journal: Radiol Med Date: 2008-07-09 Impact factor: 3.469
Authors: M Van Goethem; K Schelfout; L Dijckmans; J C Van Der Auwera; J Weyler; I Verslegers; I Biltjes; A De Schepper Journal: Eur Radiol Date: 2003-11-13 Impact factor: 5.315