Literature DB >> 8645300

G protein-gated K+ channel (GIRK1) protein is expressed presynaptically in the paraventricular nucleus of the hypothalamus.

K I Morishige1, A Inanobe, N Takahashi, Y Yoshimoto, H Kurachi, A Miyake, Y Tokunaga, T Maeda, Y Kurachi.   

Abstract

We prepared a specific antibody against GIRK1, the major subunit of the G protein-gated K+ (KG) channel. Immunohistochemical study revealed that GIRK1 immunoreactivity was detected in the presynaptic, but not in the postsynaptic, region in the paraventricular nucleus of the rat hypothalamus (PVN). Therefore, activation of the KG channel may underlie presynaptic inhibition of neurotransmitter release by various agonists, such as dopamine, noradrenaline, opioids, and histamine, in PVN.

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Year:  1996        PMID： 8645300     DOI： 10.1006/bbrc.1996.0400

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: a model of Down syndrome.

Authors:  Chie Harashima; David M Jacobowitz; Jassir Witta; Rosemary C Borke; Tyler K Best; Richard J Siarey; Zygmunt Galdzicki
Journal:  J Comp Neurol       Date:  2006-02-10       Impact factor: 3.215

2.  Characterization of G-protein-gated K+ channels composed of Kir3.2 subunits in dopaminergic neurons of the substantia nigra.

Authors:  A Inanobe; Y Yoshimoto; Y Horio; K I Morishige; H Hibino; S Matsumoto; Y Tokunaga; T Maeda; Y Hata; Y Takai; Y Kurachi
Journal:  J Neurosci       Date:  1999-02-01       Impact factor: 6.167

3.  Developmental regulation of G protein-gated inwardly-rectifying K+ (GIRK/Kir3) channel subunits in the brain.

Authors:  Laura Fernández-Alacid; Masahiko Watanabe; Elek Molnár; Kevin Wickman; Rafael Luján
Journal:  Eur J Neurosci       Date:  2011-11-18       Impact factor: 3.386

Review 4.  Cell signal control of the G protein-gated potassium channel and its subcellular localization.

Authors:  Yoshihisa Kurachi; Masaru Ishii
Journal:  J Physiol       Date:  2003-08-15       Impact factor: 5.182

5.  Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells.

Authors:  Laura Fernández-Alacid; Carolina Aguado; Francisco Ciruela; Ricardo Martín; José Colón; María José Cabañero; Martin Gassmann; Masahiko Watanabe; Ryuichi Shigemoto; Kevin Wickman; Bernhard Bettler; José Sánchez-Prieto; Rafael Luján
Journal:  J Neurochem       Date:  2009-06-22       Impact factor: 5.372

Review 6.  Ion Channels in the Paraventricular Hypothalamic Nucleus (PVN); Emerging Diversity and Functional Roles.

Authors:  Claire H Feetham; Fiona O'Brien; Richard Barrett-Jolley
Journal:  Front Physiol       Date:  2018-07-06       Impact factor: 4.566
  6 in total

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