Literature DB >> 8645247

Structure and regional distribution of nociceptin/orphanin FQ precursor.

T Houtani1, M Nishi, H Takeshima, T Nukada, T Sugimoto.   

Abstract

We have cloned cDNA carrying the entire coding sequence of the precursor protein for nociceptin/orphanin FQ, a neuropeptide-ligand for an opioid-receptor like G-protein coupled receptor. The deduced nociceptin/orphanin FQ precursor shows sequence similarity to the opioid peptide precursors and shares characteristic structural features particularly with preprodynorphin. In situ hybridization analysis of nociceptin precursor mRNA in the mouse central nervous system revealed that it is highly expressed in discrete neuronal sites with the pattern distinct from those of opioid peptides.

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Year:  1996        PMID： 8645247     DOI： 10.1006/bbrc.1996.0300

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  15 in total

1.  Nociceptin-induced scratching, biting and licking in mice: involvement of spinal NK1 receptors.

Authors:  T Sakurada; S Katsuyama; S Sakurada; M Inoue; K Tan-No; K Kisara; C Sakurada; H Ueda; J Sasaki
Journal:  Br J Pharmacol       Date:  1999-08       Impact factor: 8.739

Review 2.  Pharmacology of nociceptin and its receptor: a novel therapeutic target.

Authors:  G Calo'; R Guerrini; A Rizzi; S Salvadori; D Regoli
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739

3.  Nociceptin, Phe(1)psi-nociceptin(1 - 13), nocistatin and prepronociceptin(154 - 181) effects on calcium channel currents and a potassium current in rat locus coeruleus in vitro.

Authors:  M Connor; C W Vaughan; E A Jennings; R G Allen; M J Christie
Journal:  Br J Pharmacol       Date:  1999-12       Impact factor: 8.739

4.  Nociceptin/orphanin FQ suppresses adaptive immune responses in vivo and at picomolar levels in vitro.

Authors:  Benito Anton; Phillipe Leff; Joseph J Meissler; Juan C Calva; Rodolfo Acevedo; Alberto Salazar; Maura Matus; Anabel Flores; Martin Martinez; Martin W Adler; John P Gaughan; Toby K Eisenstein
Journal:  J Neuroimmune Pharmacol       Date:  2010-02-02       Impact factor: 4.147

5.  Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor.

Authors:  M Nishi; T Houtani; Y Noda; T Mamiya; K Sato; T Doi; J Kuno; H Takeshima; T Nukada; T Nabeshima; T Yamashita; T Noda; T Sugimoto
Journal:  EMBO J       Date:  1997-04-15       Impact factor: 11.598

6.  Actions of nociceptin/orphanin FQ and other prepronociceptin products on rat rostral ventromedial medulla neurons in vitro.

Authors:  C W Vaughan; M Connor; E A Jennings; S Marinelli; R G Allen; M J Christie
Journal:  J Physiol       Date:  2001-08-01       Impact factor: 5.182

7.  Actions of the ORL1 receptor ligand nociceptin on membrane properties of rat periaqueductal gray neurons in vitro.

Authors:  C W Vaughan; S L Ingram; M J Christie
Journal:  J Neurosci       Date:  1997-02-01       Impact factor: 6.167

8.  A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.

Authors:  F Jenck; J Wichmann; F M Dautzenberg; J L Moreau; A M Ouagazzal; J R Martin; K Lundstrom; A M Cesura; S M Poli; S Roever; S Kolczewski; G Adam; G Kilpatrick
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-25       Impact factor: 11.205

9.  Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to nociceptin/orphanin FQ.

Authors:  S Meis; H C Pape
Journal:  J Neurosci       Date:  1998-10-15       Impact factor: 6.167

10.  Human neutrophils as a source of nociceptin: a novel link between pain and inflammation.

Authors:  Marie-Elaine Fiset; Caroline Gilbert; Patrice E Poubelle; Marc Pouliot
Journal:  Biochemistry       Date:  2003-09-09       Impact factor: 3.162
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